Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent.

Journal Article (Journal Article)

Body composition is often altered in psychiatric disorders. Using genome-wide common genetic variation data, we calculate sex-specific genetic correlations amongst body fat %, fat mass, fat-free mass, physical activity, glycemic traits and 17 psychiatric traits (up to N = 217,568). Two patterns emerge: (1) anorexia nervosa, schizophrenia, obsessive-compulsive disorder, and education years are negatively genetically correlated with body fat % and fat-free mass, whereas (2) attention-deficit/hyperactivity disorder (ADHD), alcohol dependence, insomnia, and heavy smoking are positively correlated. Anorexia nervosa shows a stronger genetic correlation with body fat % in females, whereas education years is more strongly correlated with fat mass in males. Education years and ADHD show genetic overlap with childhood obesity. Mendelian randomization identifies schizophrenia, anorexia nervosa, and higher education as causal for decreased fat mass, with higher body fat % possibly being a causal risk factor for ADHD and heavy smoking. These results suggest new possibilities for targeted preventive strategies.

Full Text

Duke Authors

Cited Authors

  • Hübel, C; Gaspar, HA; Coleman, JRI; Hanscombe, KB; Purves, K; Prokopenko, I; Graff, M; Ngwa, JS; Workalemahu, T; ADHD Working Group of the Psychiatric Genomics Consortium, ; Meta-Analyses of Glucose and Insulin-related traits consortium (MAGIC), ; Autism Working Group of the Psychiatric Genomics Consortium, ; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, ; Eating Disorders Working Group of the Psychiatric Genomics Consortium, ; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, ; OCD & Tourette Syndrome Working Group of the Psychiatric Genomics Consortium, ; PTSD Working Group of the Psychiatric Genomics Consortium, ; Schizophrenia Working Group of the Psychiatric Genomics Consortium, ; Sex Differences Cross Disorder Working Group of the Psychiatric Genomics Consortium, ; Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, ; German Borderline Genomics Consortium, ; International Headache Genetics Consortium, ; O'Reilly, PF; Bulik, CM; Breen, G

Published Date

  • December 2019

Published In

Volume / Issue

  • 10 / 1

Start / End Page

  • 5765 -

PubMed ID

  • 31852892

Pubmed Central ID

  • PMC6920448

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

International Standard Serial Number (ISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/s41467-019-13544-0

Language

  • eng