Preeclampsia: multiple approaches for a multifactorial disease.

Journal Article (Review;Journal Article)

Preeclampsia is a pregnancy-specific disorder characterized by hypertension and excess protein excretion in the urine. It is an important cause of maternal and fetal morbidity and mortality worldwide. The disease is almost exclusive to humans and delivery of the pregnancy continues to be the only effective treatment. The disorder is probably multifactorial, although most cases of preeclampsia are characterized by abnormal maternal uterine vascular remodeling by fetally derived placental trophoblast cells. Numerous in vitro and animal models have been used to study aspects of preeclampsia, the most common being models of placental oxygen dysregulation, abnormal trophoblast invasion, inappropriate maternal vascular damage and anomalous maternal-fetal immune interactions. Investigations into the pathophysiology and treatment of preeclampsia continue to move the field forward, albeit at a frustratingly slow pace. There remains a pressing need for novel approaches, new disease models and innovative investigators to effectively tackle this complex and devastating disorder.

Full Text

Duke Authors

Cited Authors

  • Pennington, KA; Schlitt, JM; Jackson, DL; Schulz, LC; Schust, DJ

Published Date

  • January 2012

Published In

Volume / Issue

  • 5 / 1

Start / End Page

  • 9 - 18

PubMed ID

  • 22228789

Pubmed Central ID

  • PMC3255538

Electronic International Standard Serial Number (EISSN)

  • 1754-8411

International Standard Serial Number (ISSN)

  • 1754-8403

Digital Object Identifier (DOI)

  • 10.1242/dmm.008516

Language

  • eng