Viral subversion of the immune system.


This review describes the diverse array of pathways and molecular targets that are used by viruses to elude immune detection and destruction. These include targeting of pathways for major histocompatibility complex-restricted antigen presentation, apoptosis, cytokine-mediated signaling, and humoral immune responses. The continuous interactions between host and pathogens during their coevolution have shaped the immune system, but also the counter measures used by pathogens. Further study of their interactions should improve our ability to manipulate and exploit the various pathogens.

Full Text

Duke Authors

Cited Authors

  • Tortorella, D; Gewurz, BE; Furman, MH; Schust, DJ; Ploegh, HL

Published Date

  • 2000

Volume / Issue

  • 18 /

Start / End Page

  • 861 - 926

PubMed ID

  • 10837078

Digital Object Identifier (DOI)

  • 10.1146/annurev.immunol.18.1.861