Characterization of gut-derived intraepithelial lymphocyte (IEL) residing in human papillomavirus (HPV)-infected intraepithelial neoplastic lesions.

Journal Article (Journal Article)

PROBLEM: Mucosal T cells are the most likely direct effectors in host anti-human papillomavirus adaptive immunity and regression of cervical intraepithelial neoplasia (CIN) lesions. There are no studies addressing intraepithelial lymphocytes (IELs) in CIN lesions. METHOD OF STUDY: Cervical lymphocytes were collected using cytobrushes from patients with CIN and analyzed by FACS analysis. Comparisons were made between populations of cervical T cells in CIN regressors and non-regressors. RESULTS: A median of 74% of cervical lymphocytes were CD3(+) T cells. Populations of integrin αEβ7(+) IEL in CIN lesions varied markedly among patients (6-57%). Approximately half of integrin β7(+) T cells were CD45RA-negative memory T cells. The number of integrin αEβ7(+) cells among cervical T cells was significantly higher in CIN regressors when compared to non-regressors. CONCLUSION: Higher cervical IEL numbers are associated with spontaneous regression of CIN. Accumulation of cervical integrin αEβ7(+) IEL may be necessary for local adaptive effector functions.

Full Text

Duke Authors

Cited Authors

  • Kojima, S; Kawana, K; Fujii, T; Yokoyama, T; Miura, S; Tomio, K; Tomio, A; Yamashita, A; Adachi, K; Sato, H; Nagamatsu, T; Schust, DJ; Kozuma, S; Taketani, Y

Published Date

  • November 2011

Published In

Volume / Issue

  • 66 / 5

Start / End Page

  • 435 - 443

PubMed ID

  • 21749545

Electronic International Standard Serial Number (EISSN)

  • 1600-0897

Digital Object Identifier (DOI)

  • 10.1111/j.1600-0897.2011.01041.x


  • eng

Conference Location

  • Denmark