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Cyclic regulation of T-Bet and GATA-3 in human endometrium.

Publication ,  Journal Article
Inman, D; Kawana, K; Schust, D; Lininger, R; Young, S
Published in: Reprod Sci
January 2008

Endometrial cytokine expression is poorly understood. T-Bet and GATA-3 regulate cytokine expression in T-lymphocytes. Previous work has demonstrated expression of T-Bet in human endometrium. Changes in human endometrial T-Bet and GATA-3 mRNA and protein expression during the normal menstrual cycle were characterized. Human endometrium from each phase of the menstrual cycle underwent real-time reverse-transcriptase polymerase chain reaction and immunohistochemistry to examine expression and localization. T-Bet and GATA-3 mRNA were increased in the late secretory phase. Progesterone receptor (PR) mRNA was increased during the proliferative and early secretory phases. T-Bet and GATA-3 proteins localized cytoplasmically in the late secretory phase. PR protein displayed nuclear localization and maximal immunostaining during the early secretory phase. T-Bet and GATA-3 are expressed in endometrial epithelium cyclically during the menstrual cycle. T-Bet and GATA-3 are both upregulated during the late secretory phase and in the same cell types. The expression patterns of T-Bet and GATA-3 oppose PR, suggesting antagonistic function and/or regulation between PR and T-Bet/GATA-3.

Duke Scholars

Published In

Reprod Sci

DOI

EISSN

1933-7205

Publication Date

January 2008

Volume

15

Issue

1

Start / End Page

83 / 90

Location

United States

Related Subject Headings

  • T-Box Domain Proteins
  • Reverse Transcriptase Polymerase Chain Reaction
  • Receptors, Progesterone
  • RNA, Messenger
  • Obstetrics & Reproductive Medicine
  • Menstrual Cycle
  • Male
  • Luteinizing Hormone
  • Humans
  • Gene Expression
 

Citation

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Inman, D., Kawana, K., Schust, D., Lininger, R., & Young, S. (2008). Cyclic regulation of T-Bet and GATA-3 in human endometrium. Reprod Sci, 15(1), 83–90. https://doi.org/10.1177/1933719107309690
Inman, Danielle, Kei Kawana, Danny Schust, Ruth Lininger, and Steven Young. “Cyclic regulation of T-Bet and GATA-3 in human endometrium.Reprod Sci 15, no. 1 (January 2008): 83–90. https://doi.org/10.1177/1933719107309690.
Inman D, Kawana K, Schust D, Lininger R, Young S. Cyclic regulation of T-Bet and GATA-3 in human endometrium. Reprod Sci. 2008 Jan;15(1):83–90.
Inman, Danielle, et al. “Cyclic regulation of T-Bet and GATA-3 in human endometrium.Reprod Sci, vol. 15, no. 1, Jan. 2008, pp. 83–90. Pubmed, doi:10.1177/1933719107309690.
Inman D, Kawana K, Schust D, Lininger R, Young S. Cyclic regulation of T-Bet and GATA-3 in human endometrium. Reprod Sci. 2008 Jan;15(1):83–90.
Journal cover image

Published In

Reprod Sci

DOI

EISSN

1933-7205

Publication Date

January 2008

Volume

15

Issue

1

Start / End Page

83 / 90

Location

United States

Related Subject Headings

  • T-Box Domain Proteins
  • Reverse Transcriptase Polymerase Chain Reaction
  • Receptors, Progesterone
  • RNA, Messenger
  • Obstetrics & Reproductive Medicine
  • Menstrual Cycle
  • Male
  • Luteinizing Hormone
  • Humans
  • Gene Expression