Can viruses help us to understand and classify the MHC class I molecules at the maternal-fetal interface?

Conference Paper

Placental expression of HLA-C, HLA-E, and HLA-G locus products is now well described. However, to date, the functional relevance of these MHC class I products at the maternal-fetal interface is incompletely described. We propose here that HLA-C, -E, and -G comprise a distinct and cohesive group of MHC class I products. This hypothesis is supported by a growing body of data, including that obtained through the study of viral immune evasion. Continued investigation of viral interactions with MHC class I products promises to help us to define those specific attributes of HLA-C, -E, and -G that define their common characteristics.

Full Text

Duke Authors

Cited Authors

  • Furman, MH; Ploegh, HL; Schust, DJ

Published Date

  • November 2000

Published In

Volume / Issue

  • 61 / 11

Start / End Page

  • 1169 - 1176

PubMed ID

  • 11137223

International Standard Serial Number (ISSN)

  • 0198-8859

Digital Object Identifier (DOI)

  • 10.1016/s0198-8859(00)00203-2

Conference Location

  • United States