Induction of maternal tolerance to fetal alloantigens by RANTES production.

Journal Article (Journal Article)

PROBLEM: Previous studies have demonstrated a requirement for RANTES (regulated on activated normal T-cell expressed, and secreted) at immune privileged sites; we have investigated the role of RANTES in the induction of maternal-fetal tolerance. METHOD OF STUDY: Endometrial and peripheral T lymphocytes were obtained from women with recurrent pregnancy losses (RPLs) and fertile women. RANTES modulation by progesterone or paternal alloantigens was measured by enzyme-linked immunosorbent assay or flow cytometry analysis. RESULTS: Progesterone significantly increased intracellular RANTES expression in CD4+ and CD8+ endometrial T cells. Moreover, alloreactive lymphocytes from RPL patients produced lower RANTES levels when compared with those from fertile women. At the local level, treatment with recombinant RANTES induced a decrease in CCR5 and CXCR4 messenger RNA that correlated with an increase in T-bet expression. RPL patients and normally fertile women express RANTES similarly, but differ in their patterns of RANTES receptor expression. CONCLUSION: RANTES may be implicated in the local induction of a Th1-type response necessary for successful implantation. Altered response to RANTES stimulation among some RPL patients may be responsible for poor pregnancy outcomes.

Full Text

Duke Authors

Cited Authors

  • Ramhorst, R; Patel, R; Corigliano, A; Etchepareborda, JJ; Fainboim, L; Schust, D

Published Date

  • 2006

Published In

Volume / Issue

  • 56 / 5-6

Start / End Page

  • 302 - 311

PubMed ID

  • 17076674

International Standard Serial Number (ISSN)

  • 1046-7408

Digital Object Identifier (DOI)

  • 10.1111/j.1600-0897.2006.00430.x


  • eng

Conference Location

  • Denmark