Immune interactions at the maternal-fetal interface: a focus on antigen presentation.

Journal Article (Journal Article;Review)

PROBLEMS: Viruses and fetuses face similar immunologic challenges. Each must evade immune detection and destruction. The virus must avoid host recognition of intracellular infection; the fetus allogenic recognition. Each has manipulated the process of antigen presentation to allow survival in an immunologic environment otherwise predictably hostile. How have these approaches co-evolved? What can they teach us about viral pathogenesis and immunologic interactions at the maternal-fetal interface? METHOD OF STUDY: Review of relevant literature. RESULTS: Special classical and non-classical MHC class I products are spared from downregulation in the placenta and from viral immunoevasive strategies. CONCLUSIONS: Viruses rely upon some of the same strategies to avoid immune detection as do trophoblast cells. In the future, viral infections may prove a useful tool for studies of immunology at the maternal-fetal interface.

Full Text

Duke Authors

Cited Authors

  • Huddleston, H; Schust, DJ

Published Date

  • April 2004

Published In

Volume / Issue

  • 51 / 4

Start / End Page

  • 283 - 289

PubMed ID

  • 15212681

International Standard Serial Number (ISSN)

  • 1046-7408

Digital Object Identifier (DOI)

  • 10.1111/j.1600-0897.2004.00157.x

Language

  • eng

Conference Location

  • Denmark