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Comparison of Quality of Life and Outcomes between Haploidentical and Matched Related/Unrelated Donor Allogeneic Hematopoietic Cell Transplantation.

Publication ,  Journal Article
Hong, S; Rybicki, L; Mclellan, L; Dabney, J; Gerds, AT; Rotz, SJ; Kalaycio, M; Hanna, R; Hamilton, BK; Majhail, NS; Sobecks, RM
Published in: Transplant Cell Ther
April 2022

Haploidentical (haplo) donor grafts are a well-established alternative donor source for allogeneic hematopoietic cell transplantation (HCT); however, data comparing health-realted quality of life (HRQOL) measures between haplo-HCT and HCT using other donor sources are lacking. We hypothesized that post-transplantation HRQOL might not differ between haplo-HCT and HCT with other graft sources. We conducted a single-institution retrospective analysis comparing HRQOL of haplo-HCT with matched-related donor (MRD) HCT and matched unrelated donor (MUD) HCT for hematologic diseases. We included 90 haplo, 102 MRD, and 229 MUD adult first allogeneic HCTs performed between May 2014 and December 2019. HRQOL for haplo-HCT, MRD-HCT, and MUD-HCT were compared separately for myeloablative conditioning (MAC) and reduced-intensity conditioning (RIC). HRQOL was assessed using the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) scale pretransplantation and at days +100 and +180 post-transplantation. MAC haplo-HCT showed no difference in all domains of HRQOL and other transplantation outcomes, including overall survival, compared with MAC MRD/MUD-HCT, except for a higher incidence of non-cytomegalovirus infections (P = .003). RIC haplo-HCT was associated with significantly better emotional well-being (P = .008) and functional well-being (P = .011) compared with MUD-HCT. RIC haplo-HCT was associated with higher rates of non-cytomegalovirus infections (P < .001) and relapse mortality (P = .044) but a lower rate of nonrelapse mortality (P = .008) compared with RIC MUD-HCT. Haplo-HCT had comparable total HRQOL scores and overall survival to MRD/MUD-HCT in both the MAC and RIC cohorts. Interrogation of HRQOL among disease-specific groups may further elucidate the existence of any additional benefits with these different transplantation modalities.

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Published In

Transplant Cell Ther

DOI

EISSN

2666-6367

Publication Date

April 2022

Volume

28

Issue

4

Start / End Page

217.e1 / 217.e6

Location

United States

Related Subject Headings

  • Unrelated Donors
  • Transplantation Conditioning
  • Retrospective Studies
  • Quality of Life
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Adult
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
 

Citation

APA
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MLA
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Hong, S., Rybicki, L., Mclellan, L., Dabney, J., Gerds, A. T., Rotz, S. J., … Sobecks, R. M. (2022). Comparison of Quality of Life and Outcomes between Haploidentical and Matched Related/Unrelated Donor Allogeneic Hematopoietic Cell Transplantation. Transplant Cell Ther, 28(4), 217.e1-217.e6. https://doi.org/10.1016/j.jtct.2022.01.012
Hong, Sanghee, Lisa Rybicki, Linda Mclellan, Jane Dabney, Aaron T. Gerds, Seth J. Rotz, Matt Kalaycio, et al. “Comparison of Quality of Life and Outcomes between Haploidentical and Matched Related/Unrelated Donor Allogeneic Hematopoietic Cell Transplantation.Transplant Cell Ther 28, no. 4 (April 2022): 217.e1-217.e6. https://doi.org/10.1016/j.jtct.2022.01.012.
Hong S, Rybicki L, Mclellan L, Dabney J, Gerds AT, Rotz SJ, et al. Comparison of Quality of Life and Outcomes between Haploidentical and Matched Related/Unrelated Donor Allogeneic Hematopoietic Cell Transplantation. Transplant Cell Ther. 2022 Apr;28(4):217.e1-217.e6.
Hong, Sanghee, et al. “Comparison of Quality of Life and Outcomes between Haploidentical and Matched Related/Unrelated Donor Allogeneic Hematopoietic Cell Transplantation.Transplant Cell Ther, vol. 28, no. 4, Apr. 2022, pp. 217.e1-217.e6. Pubmed, doi:10.1016/j.jtct.2022.01.012.
Hong S, Rybicki L, Mclellan L, Dabney J, Gerds AT, Rotz SJ, Kalaycio M, Hanna R, Hamilton BK, Majhail NS, Sobecks RM. Comparison of Quality of Life and Outcomes between Haploidentical and Matched Related/Unrelated Donor Allogeneic Hematopoietic Cell Transplantation. Transplant Cell Ther. 2022 Apr;28(4):217.e1-217.e6.

Published In

Transplant Cell Ther

DOI

EISSN

2666-6367

Publication Date

April 2022

Volume

28

Issue

4

Start / End Page

217.e1 / 217.e6

Location

United States

Related Subject Headings

  • Unrelated Donors
  • Transplantation Conditioning
  • Retrospective Studies
  • Quality of Life
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Adult
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences