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Reduction in cerebral oxygen metabolism in subcortical regions may be a biomarker of cognitive decline in people living with human immunodeficiency virus.

Publication ,  Journal Article
Sen, S; An, H; Sollman, M; Oakes, J; Eron, J; Robertson, K; Powers, W
Published in: Eur J Neurol
April 2022

BACKGROUND AND PURPOSE: Regional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO2 ) in whole brain, white matter, gray matter and lenticular nuclei were studied in people living with human immunodeficiency virus (PLHIV) as well as HIV-associated neurocognitive disorder (HAND). METHODS: Treatment-naïve PLHIV underwent neurocognitive assessment and magnetic resonance (MR) measurement of rCBF and rCMRO2 with repeat after 12 months of antiretroviral therapy (ART). Age- and sex-matched controls underwent single MR measurements. Regional CBF and rCMRO2 were compared amongst symptomatic, asymptomatic, normal HAND and controls using analysis of variance. Longitudinal analysis of HAND worsening (≥1 category) was assessed after 12 months of ART and correlated with rCBF and rCMRO2 measured by MR imaging using the paired-sample t test. RESULTS: Thirty PLHIV completed baseline and 12-month assessments (29 with rCMRO2 measurement). At baseline HAND assessment, 13% had no cognitive impairment, 27% had asymptomatic neurocognitive impairment, 60% had mild neurocognitive disorder and none had HIV-associated dementia. At 12 months, 13% had no cognitive impairment, 20% had asymptomatic neurocognitive impairment, 50% had mild neurocognitive disorder and 17% had HIV-associated dementia. In those without HAND worsening (N = 21) rCMRO2 remained stable and in those with HAND worsening (N = 8) rCMRO2 measurement declined from baseline to 12 months in white matter (2.05 ± 0.40 to 1.73 ± 0.51, p = 0.03) and lenticular nuclei (4.32 ± 0.39 to 4.00 ± 0.51, p = 0.05). CONCLUSIONS: In recently diagnosed PLHIV, no association was found between rCBF or rCMRO2 and cognitive impairment at baseline. There was a reduction in rCMRO2 in those with worsening of cognitive function at 12 months on ART. Reduction in rCMRO2 may be a biomarker of cognitive decline in PLHIV.

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Published In

Eur J Neurol

DOI

EISSN

1468-1331

Publication Date

April 2022

Volume

29

Issue

4

Start / End Page

1062 / 1074

Location

England

Related Subject Headings

  • Oxygen
  • Neurology & Neurosurgery
  • Humans
  • HIV Infections
  • HIV
  • Cognitive Dysfunction
  • Cerebrovascular Circulation
  • Brain
  • Biomarkers
  • 3209 Neurosciences
 

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Sen, S., An, H., Sollman, M., Oakes, J., Eron, J., Robertson, K., & Powers, W. (2022). Reduction in cerebral oxygen metabolism in subcortical regions may be a biomarker of cognitive decline in people living with human immunodeficiency virus. Eur J Neurol, 29(4), 1062–1074. https://doi.org/10.1111/ene.15196
Sen, Souvik, Hongyu An, Myriam Sollman, Jonathan Oakes, Joseph Eron, Kevin Robertson, and William Powers. “Reduction in cerebral oxygen metabolism in subcortical regions may be a biomarker of cognitive decline in people living with human immunodeficiency virus.Eur J Neurol 29, no. 4 (April 2022): 1062–74. https://doi.org/10.1111/ene.15196.
Sen, Souvik, et al. “Reduction in cerebral oxygen metabolism in subcortical regions may be a biomarker of cognitive decline in people living with human immunodeficiency virus.Eur J Neurol, vol. 29, no. 4, Apr. 2022, pp. 1062–74. Pubmed, doi:10.1111/ene.15196.
Sen S, An H, Sollman M, Oakes J, Eron J, Robertson K, Powers W. Reduction in cerebral oxygen metabolism in subcortical regions may be a biomarker of cognitive decline in people living with human immunodeficiency virus. Eur J Neurol. 2022 Apr;29(4):1062–1074.
Journal cover image

Published In

Eur J Neurol

DOI

EISSN

1468-1331

Publication Date

April 2022

Volume

29

Issue

4

Start / End Page

1062 / 1074

Location

England

Related Subject Headings

  • Oxygen
  • Neurology & Neurosurgery
  • Humans
  • HIV Infections
  • HIV
  • Cognitive Dysfunction
  • Cerebrovascular Circulation
  • Brain
  • Biomarkers
  • 3209 Neurosciences