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Improved synthesis of 1-[11C]D-glucose.

Publication ,  Journal Article
Dence, CS; Powers, WJ; Welch, MJ
Published in: Appl Radiat Isot
June 1993

An improved synthesis of 1-[11C]D-glucose is described. The major improvement is achieved when a 0.033 M borate buffer at pH 8.1 is used to effect the condensation of d-arabinose with NH4(11)CN. Subsequent reduction of the 1-[11C]D-aldonitriles gives the epimeric sugars 1-[11C]D-glucose and 1-[11C]D-mannose in a ratio of 1.8 +/- 0.57 as the major products. The decay corrected radiochemical yield is about 30% for the mixture of sugars. The overall synthesis, starting with the production of NH4(11)CN, is conducted in a dedicated remote system. The remote gantry was easy to build with commercially available valves and glassware, and has been practically trouble-free after more than 2 years of use. Improved purification and quality control of the final product uses ion chromatography and a more efficient resin, and is also described. A preliminary PET study on a macaque has been conducted using 1-[11C]D-glucose obtained with this new improved synthesis.

Duke Scholars

Published In

Appl Radiat Isot

DOI

ISSN

0969-8043

Publication Date

June 1993

Volume

44

Issue

6

Start / End Page

971 / 980

Location

England

Related Subject Headings

  • Tomography, Emission-Computed
  • Nuclear Medicine & Medical Imaging
  • Macaca
  • Glucose
  • Carbon Radioisotopes
  • Animals
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
  • 0299 Other Physical Sciences
 

Citation

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Chicago
ICMJE
MLA
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Dence, C. S., Powers, W. J., & Welch, M. J. (1993). Improved synthesis of 1-[11C]D-glucose. Appl Radiat Isot, 44(6), 971–980. https://doi.org/10.1016/0969-8043(93)90053-d
Dence, C. S., W. J. Powers, and M. J. Welch. “Improved synthesis of 1-[11C]D-glucose.Appl Radiat Isot 44, no. 6 (June 1993): 971–80. https://doi.org/10.1016/0969-8043(93)90053-d.
Dence CS, Powers WJ, Welch MJ. Improved synthesis of 1-[11C]D-glucose. Appl Radiat Isot. 1993 Jun;44(6):971–80.
Dence, C. S., et al. “Improved synthesis of 1-[11C]D-glucose.Appl Radiat Isot, vol. 44, no. 6, June 1993, pp. 971–80. Pubmed, doi:10.1016/0969-8043(93)90053-d.
Dence CS, Powers WJ, Welch MJ. Improved synthesis of 1-[11C]D-glucose. Appl Radiat Isot. 1993 Jun;44(6):971–980.
Journal cover image

Published In

Appl Radiat Isot

DOI

ISSN

0969-8043

Publication Date

June 1993

Volume

44

Issue

6

Start / End Page

971 / 980

Location

England

Related Subject Headings

  • Tomography, Emission-Computed
  • Nuclear Medicine & Medical Imaging
  • Macaca
  • Glucose
  • Carbon Radioisotopes
  • Animals
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
  • 0299 Other Physical Sciences