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Physiological responses to focal cerebral ischemia in humans.

Publication ,  Journal Article
Powers, WJ; Grubb, RL; Raichle, ME
Published in: Ann Neurol
November 1984

Positron emission tomography (PET) was used to investigate the regional hemodynamic and metabolic changes that accompany focal reductions in cerebral blood flow to ischemic but uninfarcted regions of the brain. Studies were performed on 7 patients chosen from a larger group of subjects with transient ischemic attacks and normal computed tomographic findings, specifically because their PET studies showed decreased blood flow to the symptomatic hemisphere rather than symmetrical flow to the two hemispheres. In regions with decreased blood flow, the cerebral metabolic rate for oxygen was also decreased, but to a lesser degree. Cerebral blood volume, vascular mean transit time, and fractional extraction of oxygen from blood were all increased. These findings indicate that cerebral oxygen metabolism was maintained in the face of decreased blood flow by local compensatory mechanisms that included dilation of intraparenchymal blood vessels and increased transfer of oxygen from blood to tissue. Such knowledge of the physiological characteristics of ischemic, uninfarcted brain is important if PET is to be used clinically to differentiate reversible cerebral ischemia from irreversible infarction.

Duke Scholars

Published In

Ann Neurol

DOI

ISSN

0364-5134

Publication Date

November 1984

Volume

16

Issue

5

Start / End Page

546 / 552

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Regional Blood Flow
  • Oxygen Consumption
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Female
  • Cerebrovascular Circulation
  • Brain Ischemia
 

Citation

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Powers, W. J., Grubb, R. L., & Raichle, M. E. (1984). Physiological responses to focal cerebral ischemia in humans. Ann Neurol, 16(5), 546–552. https://doi.org/10.1002/ana.410160504
Powers, W. J., R. L. Grubb, and M. E. Raichle. “Physiological responses to focal cerebral ischemia in humans.Ann Neurol 16, no. 5 (November 1984): 546–52. https://doi.org/10.1002/ana.410160504.
Powers WJ, Grubb RL, Raichle ME. Physiological responses to focal cerebral ischemia in humans. Ann Neurol. 1984 Nov;16(5):546–52.
Powers, W. J., et al. “Physiological responses to focal cerebral ischemia in humans.Ann Neurol, vol. 16, no. 5, Nov. 1984, pp. 546–52. Pubmed, doi:10.1002/ana.410160504.
Powers WJ, Grubb RL, Raichle ME. Physiological responses to focal cerebral ischemia in humans. Ann Neurol. 1984 Nov;16(5):546–552.
Journal cover image

Published In

Ann Neurol

DOI

ISSN

0364-5134

Publication Date

November 1984

Volume

16

Issue

5

Start / End Page

546 / 552

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Regional Blood Flow
  • Oxygen Consumption
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Female
  • Cerebrovascular Circulation
  • Brain Ischemia