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Autoregulation of cerebral blood flow to changes in arterial pressure in mild Alzheimer's disease.

Publication ,  Journal Article
Zazulia, AR; Videen, TO; Morris, JC; Powers, WJ
Published in: J Cereb Blood Flow Metab
November 2010

Studies in transgenic mice overexpressing amyloid precursor protein (APP) demonstrate impaired autoregulation of cerebral blood flow (CBF) to changes in arterial pressure and suggest that cerebrovascular dysfunction may be critically important in the development of pathological Alzheimer's disease (AD). Given the relevance of such a finding for guiding hypertension treatment in the elderly, we assessed autoregulation in individuals with AD. Twenty persons aged 75±6 years with very mild or mild symptomatic AD (Clinical Dementia Rating 0.5 or 1.0) underwent (15)O-positron emission tomography (PET) CBF measurements before and after mean arterial pressure (MAP) was lowered from 107±13 to 92±9 mm Hg with intravenous nicardipine; (11)C-PIB-PET imaging and magnetic resonance imaging (MRI) were also obtained. There were no significant differences in mean CBF before and after MAP reduction in the bilateral hemispheres (-0.9±5.2 mL per 100 g per minute, P=0.4, 95% confidence interval (CI)=-3.4 to 1.5), cortical borderzones (-1.9±5.0 mL per 100 g per minute, P=0.10, 95% CI=-4.3 to 0.4), regions of T2W-MRI-defined leukoaraiosis (-0.3±4.4 mL per 100 g per minute, P=0.85, 95% CI=-3.3 to 3.9), or regions of peak (11)C-PIB uptake (-2.5±7.7 mL per 100 g per minute, P=0.30, 95% CI=-7.7 to 2.7). The absence of significant change in CBF with a 10 to 15 mm Hg reduction in MAP within the normal autoregulatory range demonstrates that there is neither a generalized nor local defect of autoregulation in AD.

Duke Scholars

Published In

J Cereb Blood Flow Metab

DOI

EISSN

1559-7016

Publication Date

November 2010

Volume

30

Issue

11

Start / End Page

1883 / 1889

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Positron-Emission Tomography
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Leukoaraiosis
  • Humans
  • Homeostasis
  • Female
  • Cerebrovascular Circulation
 

Citation

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Zazulia, A. R., Videen, T. O., Morris, J. C., & Powers, W. J. (2010). Autoregulation of cerebral blood flow to changes in arterial pressure in mild Alzheimer's disease. J Cereb Blood Flow Metab, 30(11), 1883–1889. https://doi.org/10.1038/jcbfm.2010.135
Zazulia, Allyson R., Tom O. Videen, John C. Morris, and William J. Powers. “Autoregulation of cerebral blood flow to changes in arterial pressure in mild Alzheimer's disease.J Cereb Blood Flow Metab 30, no. 11 (November 2010): 1883–89. https://doi.org/10.1038/jcbfm.2010.135.
Zazulia AR, Videen TO, Morris JC, Powers WJ. Autoregulation of cerebral blood flow to changes in arterial pressure in mild Alzheimer's disease. J Cereb Blood Flow Metab. 2010 Nov;30(11):1883–9.
Zazulia, Allyson R., et al. “Autoregulation of cerebral blood flow to changes in arterial pressure in mild Alzheimer's disease.J Cereb Blood Flow Metab, vol. 30, no. 11, Nov. 2010, pp. 1883–89. Pubmed, doi:10.1038/jcbfm.2010.135.
Zazulia AR, Videen TO, Morris JC, Powers WJ. Autoregulation of cerebral blood flow to changes in arterial pressure in mild Alzheimer's disease. J Cereb Blood Flow Metab. 2010 Nov;30(11):1883–1889.
Journal cover image

Published In

J Cereb Blood Flow Metab

DOI

EISSN

1559-7016

Publication Date

November 2010

Volume

30

Issue

11

Start / End Page

1883 / 1889

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Positron-Emission Tomography
  • Neurology & Neurosurgery
  • Male
  • Magnetic Resonance Imaging
  • Leukoaraiosis
  • Humans
  • Homeostasis
  • Female
  • Cerebrovascular Circulation