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Cerebral mitochondrial metabolism in early Parkinson's disease.

Publication ,  Journal Article
Powers, WJ; Videen, TO; Markham, J; Black, KJ; Golchin, N; Perlmutter, JS
Published in: J Cereb Blood Flow Metab
October 2008

Abnormal cerebral energy metabolism owing to dysfunction of mitochondrial electron transport has been implicated in the pathogenesis of Parkinson's disease (PD). However, in vivo data of mitochondrial dysfunction have been inconsistent. We directly investigated mitochondrial oxidative metabolism in vivo in 12 patients with early, never-medicated PD and 12 age-matched normal controls by combined measurements of the cerebral metabolic rate of oxygen (CMRO(2)) and the cerebral metabolic rate of glucose (CMRglc) with positron emission tomography. The primary analysis showed a statistically significant 24% increase in bihemispheric CMRO(2) and no change in CMRO(2)/CMRglc. These findings are inconsistent with a defect in mitochondrial oxidative phosphorylation owing to reduced activity of the mitochondrial electron transport system (ETS). Because PD symptoms were already manifest, deficient energy production owing to a reduced activity of the mitochondrial ETS cannot be a primary mechanism of neuronal death in early PD. Alternatively, this general increase in CMRO(2) could be due not to an increased metabolic demand but to an uncoupling of ATP production from oxidation in the terminal stage of oxidative phosphorylation. Whether this is the case in early PD and whether it is important in the pathogenesis of PD will require further study.

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Published In

J Cereb Blood Flow Metab

DOI

EISSN

1559-7016

Publication Date

October 2008

Volume

28

Issue

10

Start / End Page

1754 / 1760

Location

United States

Related Subject Headings

  • Positron-Emission Tomography
  • Parkinson Disease
  • Oxygen
  • Oxidative Phosphorylation
  • Neurology & Neurosurgery
  • Mitochondria
  • Middle Aged
  • Male
  • Humans
  • Glucose
 

Citation

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Powers, W. J., Videen, T. O., Markham, J., Black, K. J., Golchin, N., & Perlmutter, J. S. (2008). Cerebral mitochondrial metabolism in early Parkinson's disease. J Cereb Blood Flow Metab, 28(10), 1754–1760. https://doi.org/10.1038/jcbfm.2008.63
Powers, William J., Tom O. Videen, Joanne Markham, Kevin J. Black, Nima Golchin, and Joel S. Perlmutter. “Cerebral mitochondrial metabolism in early Parkinson's disease.J Cereb Blood Flow Metab 28, no. 10 (October 2008): 1754–60. https://doi.org/10.1038/jcbfm.2008.63.
Powers WJ, Videen TO, Markham J, Black KJ, Golchin N, Perlmutter JS. Cerebral mitochondrial metabolism in early Parkinson's disease. J Cereb Blood Flow Metab. 2008 Oct;28(10):1754–60.
Powers, William J., et al. “Cerebral mitochondrial metabolism in early Parkinson's disease.J Cereb Blood Flow Metab, vol. 28, no. 10, Oct. 2008, pp. 1754–60. Pubmed, doi:10.1038/jcbfm.2008.63.
Powers WJ, Videen TO, Markham J, Black KJ, Golchin N, Perlmutter JS. Cerebral mitochondrial metabolism in early Parkinson's disease. J Cereb Blood Flow Metab. 2008 Oct;28(10):1754–1760.
Journal cover image

Published In

J Cereb Blood Flow Metab

DOI

EISSN

1559-7016

Publication Date

October 2008

Volume

28

Issue

10

Start / End Page

1754 / 1760

Location

United States

Related Subject Headings

  • Positron-Emission Tomography
  • Parkinson Disease
  • Oxygen
  • Oxidative Phosphorylation
  • Neurology & Neurosurgery
  • Mitochondria
  • Middle Aged
  • Male
  • Humans
  • Glucose