Activation of human medial prefrontal cortex during autonomic responses to hypoglycemia.

Journal Article (Journal Article)

Studies in humans implicate the medial prefrontal cortex (MPFC) in complex cognitive and emotional states. We measured regional cerebral blood flow (CBF) four times each during euglycemia (5.2 +/- 0.2 mmol/liter) and hypoglycemia (3.0 +/- 0.3 mmol/liter) in nine normal human volunteers. Autonomic responses during hypoglycemia were manifested by increases in neurogenic symptoms, heart rate, and plasma levels of epinephrine, norepinephrine, and pancreatic polypeptide. Typical symptoms of hypoglycemia were mild, and none reflected evidence of cognitive or emotional stress. Quantitative CBF fell 6-8% in the cerebrum, brainstem, and cerebellum. Analysis of regional CBF differences identified neuronal activation during hypoglycemia in bilateral MPFC (areas 24 and 32) and bilateral thalamus. These results provide evidence that the MPFC participates in the autonomic responses to simple physiological stimuli in humans.

Full Text

Duke Authors

Cited Authors

  • Teves, D; Videen, TO; Cryer, PE; Powers, WJ

Published Date

  • April 20, 2004

Published In

Volume / Issue

  • 101 / 16

Start / End Page

  • 6217 - 6221

PubMed ID

  • 15026569

Pubmed Central ID

  • PMC395949

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0307048101


  • eng

Conference Location

  • United States