The role of topical probiotics on wound healing: A review of animal and human studies.

Journal Article (Journal Article;Review)

Pathogenic, opportunistic, and commensal bacterial coexist in the intestinal tract, and imbalances among these strains have been linked to systemic inflammation and a variety of disease states. Similarly, human skin plays an important role as an interface between the body and the environment with an estimated 1 billion microbes per square centimetres. Skin microbiome fluctuations that cause increases in pathologic bacteria, either because of individual and/or environmental factors, can lead to disease states at the skin level ranging from inflammatory conditions to infections. As wounds are inherently associated with perturbations in the local microflora due to injury and activation of the immune responses, the addition of topical probiotics could be a means to prevent infection, regulate inflammation, and potentially augment healing. The goal of this review is to analyse the impact the skin microbiome has on cutaneous wound healing with a focus on developing proposed treatment algorithms and support for their therapeutic potential.

Full Text

Duke Authors

Cited Authors

  • Knackstedt, R; Knackstedt, T; Gatherwright, J

Published Date

  • December 2020

Published In

Volume / Issue

  • 17 / 6

Start / End Page

  • 1687 - 1694

PubMed ID

  • 32869480

Pubmed Central ID

  • PMC7949352

Electronic International Standard Serial Number (EISSN)

  • 1742-481X

Digital Object Identifier (DOI)

  • 10.1111/iwj.13451

Language

  • eng

Conference Location

  • England