Preservation of structural brain network hubs is associated with less severe post-stroke aphasia.

Journal Article (Journal Article)

PURPOSE: Post-stroke aphasia is typically associated with ischemic damage to cortical areas or with loss of connectivity among spared brain regions. It remains unclear whether the participation of spared brain regions as networks hubs affects the severity of aphasia. METHODS: We evaluated language performance and magnetic resonance imaging from 44 participants with chronic aphasia post-stroke. The individual structural brain connectomes were constructed from diffusion tensor. Hub regions were defined in accordance with the rich club classification and studied in relation with language performance. RESULTS: Number of remaining left hemisphere rich club nodes was associated with aphasia, including comprehension, repetition and naming sub-scores. Importantly, among participants with relative preservation of regions of interest for language, aphasia severity was lessened if the region was not only spared, but also participated in the remaining network as a rich club node: Brodmann area (BA) 44/45 - repetition (p = 0.009), BA 39 - repetition (p = 0.045) and naming (p <  0.01), BA 37 - fluency (p <  0.001), comprehension (p = 0.025), repetition (p <  0.001) and naming (p <  0.001). CONCLUSIONS: Disruption of language network structural hubs is directly associated with aphasia severity after stroke.

Full Text

Duke Authors

Cited Authors

  • Gleichgerrcht, E; Kocher, M; Nesland, T; Rorden, C; Fridriksson, J; Bonilha, L

Published Date

  • 2016

Published In

Volume / Issue

  • 34 / 1

Start / End Page

  • 19 - 28

PubMed ID

  • 26599472

Electronic International Standard Serial Number (EISSN)

  • 1878-3627

Digital Object Identifier (DOI)

  • 10.3233/RNN-150511

Language

  • eng

Conference Location

  • Netherlands