Low-level mercury, omega-3 index and neurobehavioral outcomes in an adult US coastal population.

Journal Article (Journal Article)

BACKGROUND: Neurodevelopmental effects of omega-3 fatty acids and mercury from fish consumption have been characterized in children. In contrast, neurobehavioral outcomes associated with fish are not well studied in adults. OBJECTIVE: This study of avid seafood consumers on Long Island (NY, USA) sought to define associations between mercury, seafood consumption, omega-3 fatty acids and neurobehavioral outcomes. METHODS: A computer-based test system was used to assess neurobehavioral function. Blood total Hg (Hg) and omega-3 index were measured in 199 adult avid seafood eaters, who also completed the neurobehavioral assessment and an extensive food and fish frequency and demographic questionnaire. RESULTS: For most of the outcomes considered, neither Hg nor omega-3 index was associated with neurobehavioral outcomes after adjustment for key confounding variables. Fish consumption, however, was associated with decreased odds of both self-reported fatigue (OR 0.85; 95 % CI 0.72, 1.01) and a constellation of neurologic symptoms (OR 0.79; 95 % CI 0.66, 0.96). CONCLUSIONS: Results from our study provide little evidence that omega-3 fatty acids or Hg is associated with cognitive function in adult avid seafood consumers. Larger studies are needed to confirm our finding of associations between fish consumption and decreased self-reported fatigue and neurologic impairment.

Full Text

Duke Authors

Cited Authors

  • Vacchi-Suzzi, C; Karimi, R; Kruse, D; Silbernagel, SM; Levine, KE; Rohlman, DS; Meliker, JR

Published Date

  • March 2016

Published In

Volume / Issue

  • 55 / 2

Start / End Page

  • 699 - 711

PubMed ID

  • 25832490

Electronic International Standard Serial Number (EISSN)

  • 1436-6215

Digital Object Identifier (DOI)

  • 10.1007/s00394-015-0890-5

Language

  • eng

Conference Location

  • Germany