Selection against admixture and gene regulatory divergence in a long-term primate field study.

Journal Article (Journal Article)

Genetic admixture is central to primate evolution. We combined 50 years of field observations of immigration and group demography with genomic data from ~9 generations of hybrid baboons to investigate the consequences of admixture in the wild. Despite no obvious fitness costs to hybrids, we found signatures of selection against admixture similar to those described for archaic hominins. These patterns were concentrated near genes where ancestry is strongly associated with gene expression. Our analyses also show that introgression is partially predictable across the genome. This study demonstrates the value of integrating genomic and field data for revealing how "genomic signatures of selection" (e.g., reduced introgression in low-recombination regions) manifest in nature; moreover, it underscores the importance of other primates as living models for human evolution.

Full Text

Duke Authors

Cited Authors

  • Vilgalys, TP; Fogel, AS; Anderson, JA; Mututua, RS; Warutere, JK; Siodi, IL; Kim, SY; Voyles, TN; Robinson, JA; Wall, JD; Archie, EA; Alberts, SC; Tung, J

Published Date

  • August 2022

Published In

Volume / Issue

  • 377 / 6606

Start / End Page

  • 635 - 641

PubMed ID

  • 35926022

Pubmed Central ID

  • PMC9682493

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.abm4917

Language

  • eng