Desmoplastic Melanoma of the Periorbital Region.
Desmoplastic melanoma (DM) is a rare subtype of melanoma and an even smaller proportion of periocular melanomas. Here, the authors report 2 cases of DM in the periocular region. Staged according to the American Joint Committee on Cancer (AJCC) eighth edition classification, patient 1 presented with a stage IIIC (pT4apN1cM0) DM in the left lateral canthus with upper and lower eyelid and patient 2 presented with a stage IIIB (T4aN1bM0) DM in the left brow and supraorbital region with a parotid lymph node metastasis. In both patients, the lesions were amelanotic, with inflammatory appearance, and had been noted for several years before the correct diagnosis was made. In both patients, wide excision led to large surgical defects, and perineural invasion prompted adjuvant radiation therapy postoperatively. Patient 2 was treated with an immune checkpoint inhibitor for his parotid metastasis. Ophthalmologists should be aware of DM, its neurotrophic nature, and potential to metastasize with locally advanced lesions.
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Related Subject Headings
- Skin Neoplasms
- Ophthalmology & Optometry
- Melanoma, Cutaneous Malignant
- Melanoma
- Male
- Humans
- Female
- Facial Neoplasms
- Eyelid Neoplasms
- Aged
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Skin Neoplasms
- Ophthalmology & Optometry
- Melanoma, Cutaneous Malignant
- Melanoma
- Male
- Humans
- Female
- Facial Neoplasms
- Eyelid Neoplasms
- Aged