Recent advances in OCT imaging of the lamina cribrosa.

Journal Article (Journal Article;Review)

The lamina cribrosa (LC) is believed to be the site of injury to retinal ganglion cell axons in glaucoma. The ability to visualise this structure has the potential to help increase our understanding of the disease and be useful in the early detection of glaucoma. While for many years the research on the LC was essentially dependent on histology and modelling, a number of recent advances in optical coherence tomography (OCT) have dramatically improved the ability to visualise the LC, such that it is now possible to image the LC in vivo in humans and animals. In this review, we highlight recent advances in OCT imaging of the LC, in the technology, processing and analysis, and discuss the impact that these will have on the ability to diagnose and monitor glaucoma, as well as to expand our understanding of its pathophysiology. With this manuscript, we aspire to share our excitement on the achievements and potential of recent developments as well as advise caution regarding the challenges that remain before imaging of the LC and optic nerve can be used routinely in clinical practice.

Full Text

Duke Authors

Cited Authors

  • Sigal, IA; Wang, B; Strouthidis, NG; Akagi, T; Girard, MJA

Published Date

  • July 2014

Published In

Volume / Issue

  • 98 Suppl 2 / Suppl 2

Start / End Page

  • ii34 - ii39

PubMed ID

  • 24934221

Pubmed Central ID

  • PMC4208343

Electronic International Standard Serial Number (EISSN)

  • 1468-2079

Digital Object Identifier (DOI)

  • 10.1136/bjophthalmol-2013-304751


  • eng

Conference Location

  • England