Targeted Neoadjuvant Intra-arterial Chemotherapy in Lacrimal Gland Adenoid Cystic Carcinoma: A Histological Correlation Using Apoptotic Tumor Markers.

Journal Article (Journal Article)

Neoadjuvant intra-arterial cytoreductive chemotherapy is used for the treatment of lacrimal gland adenoid cystic carcinomas (ACC) to improve outcomes in this condition with an otherwise dismal prognosis. We share our experience in the management of an advanced case of ACC using a novel, highly targeted intra-arterial cytoreductive chemotherapy delivery technique involving both the internal and external carotid circulation, with an attempt to correlate the effect histologically. Refinement of the chemotherapy delivery using the tumor's vascular anatomy and appropriate blood vessel selection may lead to future globe sparing procedures without compromising survival.

Full Text

Duke Authors

Cited Authors

  • Maniar, A; Saqi, A; Troob, SH; Belinsky, I; Charles, NC; Gobin, YP; Marr, BP

Published Date

  • January 2022

Published In

Volume / Issue

  • 38 / 1

Start / End Page

  • e28 - e33

PubMed ID

  • 34652309

Electronic International Standard Serial Number (EISSN)

  • 1537-2677

Digital Object Identifier (DOI)

  • 10.1097/IOP.0000000000002071


  • eng

Conference Location

  • United States