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The Impact of Diabetes and Prediabetes on Prevalence of Mycobacterium tuberculosis Infection Among Household Contacts of Active Tuberculosis Cases in Ethiopia.

Publication ,  Journal Article
Smith, AGC; Kempker, RR; Wassie, L; Bobosha, K; Nizam, A; Gandhi, NR; Auld, SC; Magee, MJ; Blumberg, HM ...
Published in: Open forum infectious diseases
July 2022

It is uncertain whether diabetes affects the risk of developing latent tuberculosis infection (LTBI) following exposure to Mycobacterium tuberculosis (Mtb). We assessed the relationship of diabetes or prediabetes and LTBI among close and household contacts (HHCs) of patients with active pulmonary tuberculosis (TB) disease in Addis Ababa, Ethiopia.In this cross-sectional study, we performed interferon-γ release assays, TB symptom screening, and point-of-care glycolated hemoglobin (HbA1c) testing among HHCs of active TB cases. Diabetes status was classified into diabetes (HbA1c ≥6.5% or self-reported diagnosis), prediabetes (5.7%-6.4%), and euglycemia (≤5.6%). Multivariable logistic regression was used to determine the association of diabetes with LTBI.Among 597 study participants, 123 (21%) had dysglycemia including diabetes (n = 31) or prediabetes (n = 92); 423 (71%) participants were diagnosed with LTBI. Twelve of 31 (39%) HHCs with diabetes were previously undiagnosed with diabetes. The prevalence of LTBI among HHCs with diabetes, prediabetes, and euglycemia was 87% (27/31), 73% (67/92), and 69% (329/474), respectively. In multivariable analysis adjusted for age, sex, and HIV status, the odds of LTBI among HHCs with diabetes were 2.33 (95% confidence interval [CI], .76-7.08) times the odds of LTBI without diabetes. When assessing interaction with age, the association of diabetes and LTBI was robust among participants aged ≥40 years (adjusted odds ratio [aOR], 3.68 [95% CI, .77-17.6]) but not those <40 years (aOR, 1.15 [95% CI, .22-6.1]).HHCs with diabetes may be more likely to have LTBI than those with euglycemia. Further investigations are needed to assess mechanisms by which diabetes may increase risk of LTBI after Mtb exposure.

Duke Scholars

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Published In

Open forum infectious diseases

DOI

EISSN

2328-8957

ISSN

2328-8957

Publication Date

July 2022

Volume

9

Issue

7

Start / End Page

ofac323

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences
 

Citation

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Chicago
ICMJE
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Smith, A. G. C., Kempker, R. R., Wassie, L., Bobosha, K., Nizam, A., Gandhi, N. R., … Tuberculosis Research Unit: Role of Antigen Specific Responses in the Control of TB (TBRU-ASTRa) Study Group, . (2022). The Impact of Diabetes and Prediabetes on Prevalence of Mycobacterium tuberculosis Infection Among Household Contacts of Active Tuberculosis Cases in Ethiopia. Open Forum Infectious Diseases, 9(7), ofac323. https://doi.org/10.1093/ofid/ofac323
Smith, Alison G. C., Russell R. Kempker, Liya Wassie, Kidist Bobosha, Azhar Nizam, Neel R. Gandhi, Sara C. Auld, Matthew J. Magee, Henry M. Blumberg, and Henry M. Tuberculosis Research Unit: Role of Antigen Specific Responses in the Control of TB (TBRU-ASTRa) Study Group. “The Impact of Diabetes and Prediabetes on Prevalence of Mycobacterium tuberculosis Infection Among Household Contacts of Active Tuberculosis Cases in Ethiopia.Open Forum Infectious Diseases 9, no. 7 (July 2022): ofac323. https://doi.org/10.1093/ofid/ofac323.
Smith AGC, Kempker RR, Wassie L, Bobosha K, Nizam A, Gandhi NR, et al. The Impact of Diabetes and Prediabetes on Prevalence of Mycobacterium tuberculosis Infection Among Household Contacts of Active Tuberculosis Cases in Ethiopia. Open forum infectious diseases. 2022 Jul;9(7):ofac323.
Smith, Alison G. C., et al. “The Impact of Diabetes and Prediabetes on Prevalence of Mycobacterium tuberculosis Infection Among Household Contacts of Active Tuberculosis Cases in Ethiopia.Open Forum Infectious Diseases, vol. 9, no. 7, July 2022, p. ofac323. Epmc, doi:10.1093/ofid/ofac323.
Smith AGC, Kempker RR, Wassie L, Bobosha K, Nizam A, Gandhi NR, Auld SC, Magee MJ, Blumberg HM, Tuberculosis Research Unit: Role of Antigen Specific Responses in the Control of TB (TBRU-ASTRa) Study Group. The Impact of Diabetes and Prediabetes on Prevalence of Mycobacterium tuberculosis Infection Among Household Contacts of Active Tuberculosis Cases in Ethiopia. Open forum infectious diseases. 2022 Jul;9(7):ofac323.
Journal cover image

Published In

Open forum infectious diseases

DOI

EISSN

2328-8957

ISSN

2328-8957

Publication Date

July 2022

Volume

9

Issue

7

Start / End Page

ofac323

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences