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Antenatal haemoglobin A1c and risk of large-for-gestational-age infants in a multi-ethnic cohort of women with gestational diabetes.

Publication ,  Journal Article
Katon, J; Reiber, G; Williams, MA; Yanez, D; Miller, E
Published in: Paediatr Perinat Epidemiol
May 2012

Gestational diabetes mellitus (GDM) is a risk factor for delivering a large-for-gestational-age (LGA) infant. Haemoglobin A1c (A1C) is an indicator of glycaemic control. The objective of this study was to test whether higher A1C quartile at the time of diagnosis of GDM is associated with increased risk of delivering a LGA or macrosomic infant. Women with singleton pregnancies treated for GDM at a large diabetes and pregnancy programme located in Charlotte, North Carolina, were eligible for inclusion in this retrospective cohort study. Clinical information, including A1C at diagnosis, treatment, prior medical and obstetric history, and birth data were abstracted from medical records. LGA was defined as birthweight >90th percentile for gestational age and sex and macrosomia as birthweight >4000 g. Logistic regression was used to analyse the association of A1C at GDM diagnosis with risk of delivering LGA or macrosomic infants. This study included 502 women. Prevalences of LGA and macrosomia were 4% and 6% respectively. After adjustment there was no detectable trend of increased risk for LGA (P for trend = 0.12) or macrosomia (P for trend = 0.20) across increasing quartiles of A1C at GDM diagnosis. A1C at GDM diagnosis may not be linearly associated with LGA or macrosomia, possibly because of the mediating effect of strict glycaemic control in this clinical setting.

Duke Scholars

Published In

Paediatr Perinat Epidemiol

DOI

EISSN

1365-3016

Publication Date

May 2012

Volume

26

Issue

3

Start / End Page

208 / 217

Location

England

Related Subject Headings

  • Risk Factors
  • Pregnancy
  • North Carolina
  • Maternal Age
  • Male
  • Logistic Models
  • Humans
  • Glycated Hemoglobin
  • Gestational Age
  • Fetal Macrosomia
 

Citation

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MLA
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Katon, J., Reiber, G., Williams, M. A., Yanez, D., & Miller, E. (2012). Antenatal haemoglobin A1c and risk of large-for-gestational-age infants in a multi-ethnic cohort of women with gestational diabetes. Paediatr Perinat Epidemiol, 26(3), 208–217. https://doi.org/10.1111/j.1365-3016.2012.01266.x
Katon, Jodie, Gayle Reiber, Michelle A. Williams, David Yanez, and Edith Miller. “Antenatal haemoglobin A1c and risk of large-for-gestational-age infants in a multi-ethnic cohort of women with gestational diabetes.Paediatr Perinat Epidemiol 26, no. 3 (May 2012): 208–17. https://doi.org/10.1111/j.1365-3016.2012.01266.x.
Katon J, Reiber G, Williams MA, Yanez D, Miller E. Antenatal haemoglobin A1c and risk of large-for-gestational-age infants in a multi-ethnic cohort of women with gestational diabetes. Paediatr Perinat Epidemiol. 2012 May;26(3):208–17.
Katon, Jodie, et al. “Antenatal haemoglobin A1c and risk of large-for-gestational-age infants in a multi-ethnic cohort of women with gestational diabetes.Paediatr Perinat Epidemiol, vol. 26, no. 3, May 2012, pp. 208–17. Pubmed, doi:10.1111/j.1365-3016.2012.01266.x.
Katon J, Reiber G, Williams MA, Yanez D, Miller E. Antenatal haemoglobin A1c and risk of large-for-gestational-age infants in a multi-ethnic cohort of women with gestational diabetes. Paediatr Perinat Epidemiol. 2012 May;26(3):208–217.
Journal cover image

Published In

Paediatr Perinat Epidemiol

DOI

EISSN

1365-3016

Publication Date

May 2012

Volume

26

Issue

3

Start / End Page

208 / 217

Location

England

Related Subject Headings

  • Risk Factors
  • Pregnancy
  • North Carolina
  • Maternal Age
  • Male
  • Logistic Models
  • Humans
  • Glycated Hemoglobin
  • Gestational Age
  • Fetal Macrosomia