Skip to main content
Journal cover image

Combined association of lipids and blood pressure in relation to incident cardiovascular disease in the elderly: the cardiovascular health study.

Publication ,  Journal Article
Wong, ND; Lopez, VA; Roberts, CS; Solomon, HA; Burke, GL; Kuller, L; Tracy, R; Yanez, D; Psaty, BM
Published in: Am J Hypertens
February 2010

BACKGROUND: Hypertension and dyslipidemia are highly prevalent in the elderly. We studied the combined impact of both conditions on cardiovascular disease (CVD) events. METHODS: We studied 4,311 participants aged 65-98 (61.2% female) from the Cardiovascular Health Study (CHS), a longitudinal epidemiologic study, with no prior CVD. We evaluated the relation of low-density lipoprotein (LDL), high-density lipoprotein (HDL), or non-HDL-cholesterol combined with blood pressure (BP) categories to incident CVD-including coronary heart disease (CHD) (angina, myocardial infarction (MI), angioplasty, coronary bypass surgery, or CHD death), stroke, claudication, and CVD death over 15 years. RESULTS: CVD incidence (per 1,000 person years) ranged from 38.4 when BP <120/80 mm Hg and LDL-C <100 mg/dl to 94.8 when BP >or=160/100 mm Hg and LDL-C >or=160 mg/dl, and from 28.9 when BP <120/80 mm Hg and HDL >60 mg/dl to 87.1 for a BP >or=160/100 and HDL-C <40 mg/dl. Compared with those with BP <120/80 mm Hg with either LDL-C <100 mg/dl or HDL-C >60 mg/dl, hazard ratios (HRs) for CVD events were 2.1 when BP >or=160/100 mm Hg and LDL-C >or=160 mg/dl and 2.1 when BP >or=160/100 and HDL-C <40 mg/dl (all P < 0.01), with similar results for non-HDL-C. Elevated BP was associated with increased risk across all lipid levels. Increased LDL-C added risk mainly when BP <140/90 mm Hg, but lower HDL-C also predicted CVD in those with higher BP. CONCLUSION: Increased BP confers increased risks for CVD in elderly persons across all lipid levels. Although increased LDL-C added risk mainly when BP <140/90 mm Hg, low HDL-C added risk also in those with hypertension. These results document the importance of combined hypertension and dyslipidemia.

Duke Scholars

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

February 2010

Volume

23

Issue

2

Start / End Page

161 / 167

Location

United States

Related Subject Headings

  • United States
  • Socioeconomic Factors
  • Smoking
  • Sex Factors
  • Proportional Hazards Models
  • Male
  • Lipids
  • Likelihood Functions
  • Humans
  • Health Surveys
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wong, N. D., Lopez, V. A., Roberts, C. S., Solomon, H. A., Burke, G. L., Kuller, L., … Psaty, B. M. (2010). Combined association of lipids and blood pressure in relation to incident cardiovascular disease in the elderly: the cardiovascular health study. Am J Hypertens, 23(2), 161–167. https://doi.org/10.1038/ajh.2009.216
Wong, Nathan D., Victor A. Lopez, Craig S. Roberts, Henry A. Solomon, Gregory L. Burke, Lewis Kuller, Russell Tracy, David Yanez, and Bruce M. Psaty. “Combined association of lipids and blood pressure in relation to incident cardiovascular disease in the elderly: the cardiovascular health study.Am J Hypertens 23, no. 2 (February 2010): 161–67. https://doi.org/10.1038/ajh.2009.216.
Wong ND, Lopez VA, Roberts CS, Solomon HA, Burke GL, Kuller L, et al. Combined association of lipids and blood pressure in relation to incident cardiovascular disease in the elderly: the cardiovascular health study. Am J Hypertens. 2010 Feb;23(2):161–7.
Wong, Nathan D., et al. “Combined association of lipids and blood pressure in relation to incident cardiovascular disease in the elderly: the cardiovascular health study.Am J Hypertens, vol. 23, no. 2, Feb. 2010, pp. 161–67. Pubmed, doi:10.1038/ajh.2009.216.
Wong ND, Lopez VA, Roberts CS, Solomon HA, Burke GL, Kuller L, Tracy R, Yanez D, Psaty BM. Combined association of lipids and blood pressure in relation to incident cardiovascular disease in the elderly: the cardiovascular health study. Am J Hypertens. 2010 Feb;23(2):161–167.
Journal cover image

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

February 2010

Volume

23

Issue

2

Start / End Page

161 / 167

Location

United States

Related Subject Headings

  • United States
  • Socioeconomic Factors
  • Smoking
  • Sex Factors
  • Proportional Hazards Models
  • Male
  • Lipids
  • Likelihood Functions
  • Humans
  • Health Surveys