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Exparel for Postoperative Pain Management: a Comprehensive Review.

Publication ,  Journal Article
Kaye, AD; Armstead-Williams, C; Hyatali, F; Cox, KS; Kaye, RJ; Eng, LK; Farooq Anwar, MA; Patel, PV; Patil, S; Cornett, EM
Published in: Curr Pain Headache Rep
October 23, 2020

PURPOSE OF REVIEW: Multimodal pain management is the most effective way to treat postsurgical pain. However, the use of opioids for acute pain management has unfortunately been a significant contributor to the current opioid epidemic. The use of opioids should be limited and only considered a "rescue" pain medication after other modalities of pain management have been utilized. RECENT FINDINGS: It may be difficult to curtail the use of opioids in the treatment of chronic pain; however, in the postsurgical setting, there is compelling evidence that an opioid-centric analgesic approach is not necessary for good patient outcomes and healthcare cost benefits. Opioid-related adverse effects are the leading cause of preventable harm in the hospital setting. After the realization in recent years of the many harmful effects of opioids, alternative regimens including the use of multimodal analgesia have become a standard practice in acute pain management. Exparel, a long-lasting liposomal bupivacaine local anesthetic agent, has many significant benefits in the management of postoperative pain. Overall, the literature suggests that Exparel may be a significant component for postoperative multimodal pain control owing to its efficacy and long duration of action.

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Published In

Curr Pain Headache Rep

DOI

EISSN

1534-3081

Publication Date

October 23, 2020

Volume

24

Issue

11

Start / End Page

73

Location

United States

Related Subject Headings

  • Pain, Postoperative
  • Pain Management
  • Neurology & Neurosurgery
  • Liposomes
  • Humans
  • Delayed-Action Preparations
  • Bupivacaine
  • Anesthetics, Local
  • 3214 Pharmacology and pharmaceutical sciences
  • 3209 Neurosciences
 

Citation

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Kaye, A. D., Armstead-Williams, C., Hyatali, F., Cox, K. S., Kaye, R. J., Eng, L. K., … Cornett, E. M. (2020). Exparel for Postoperative Pain Management: a Comprehensive Review. Curr Pain Headache Rep, 24(11), 73. https://doi.org/10.1007/s11916-020-00905-4
Kaye, Alan David, Cassandra Armstead-Williams, Farees Hyatali, Katherine S. Cox, Rachel J. Kaye, Lauren K. Eng, Muhammad A. Farooq Anwar, Perene V. Patel, Shilpa Patil, and Elyse M. Cornett. “Exparel for Postoperative Pain Management: a Comprehensive Review.Curr Pain Headache Rep 24, no. 11 (October 23, 2020): 73. https://doi.org/10.1007/s11916-020-00905-4.
Kaye AD, Armstead-Williams C, Hyatali F, Cox KS, Kaye RJ, Eng LK, et al. Exparel for Postoperative Pain Management: a Comprehensive Review. Curr Pain Headache Rep. 2020 Oct 23;24(11):73.
Kaye, Alan David, et al. “Exparel for Postoperative Pain Management: a Comprehensive Review.Curr Pain Headache Rep, vol. 24, no. 11, Oct. 2020, p. 73. Pubmed, doi:10.1007/s11916-020-00905-4.
Kaye AD, Armstead-Williams C, Hyatali F, Cox KS, Kaye RJ, Eng LK, Farooq Anwar MA, Patel PV, Patil S, Cornett EM. Exparel for Postoperative Pain Management: a Comprehensive Review. Curr Pain Headache Rep. 2020 Oct 23;24(11):73.
Journal cover image

Published In

Curr Pain Headache Rep

DOI

EISSN

1534-3081

Publication Date

October 23, 2020

Volume

24

Issue

11

Start / End Page

73

Location

United States

Related Subject Headings

  • Pain, Postoperative
  • Pain Management
  • Neurology & Neurosurgery
  • Liposomes
  • Humans
  • Delayed-Action Preparations
  • Bupivacaine
  • Anesthetics, Local
  • 3214 Pharmacology and pharmaceutical sciences
  • 3209 Neurosciences