The design of a heterocellular 3D architecture and its application to monitoring the behavior of cancer cells in response to the spatial distribution of endothelial cells.

Journal Article (Journal Article)

The spatial cell distribution is one of the critical features for governing cellular interactions and their consequent behaviors. Here we suggest a novel method of building a hierarchical cellular structure by stacking cell-attached microplate structures with specific configurations within hydrogel layers. This method is applied to the reconstruction of the 3D architecture of a liver lobule and the development of an experimental model of the various phases of cancer angiogenesis.

Full Text

Duke Authors

Cited Authors

  • Lee, W; Park, J

Published Date

  • October 9, 2012

Published In

Volume / Issue

  • 24 / 39

Start / End Page

  • 5339 - 5344

PubMed ID

  • 22927197

Electronic International Standard Serial Number (EISSN)

  • 1521-4095

Digital Object Identifier (DOI)

  • 10.1002/adma.201200687


  • eng

Conference Location

  • Germany