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The reliable targeting of specific drug release profiles by integrating arrays of different albumin-encapsulated microsphere types.

Publication ,  Journal Article
Lee, W; Wiseman, ME; Cho, N-J; Glenn, JS; Frank, CW
Published in: Biomaterials
December 2009

Biodegradable polymer microspheres have been successfully utilized as a medium for controlled protein or peptide-based drug release. Because the release kinetics has been typically controlled by modulating physical or chemical properties of the medium, these parameters must be optimized to obtain a specific release profile. However, due to the complexity of the release mechanism and the complicated interplay between various design parameters of the release medium, detailed prediction of the resulting release profile is a challenge. Herein we suggest a simple method to target specific release profiles more efficiently by integrating release profiles for an array of different microsphere types. This scheme is based on our observation that the resulting release profile from a mixture of different samples can be predicted as the linear summation of the individually measured release profiles of each sample. Hence, by employing a linear equation at each time point and formulating them as a matrix equation, we could determine how much of each microsphere type to include in a mixture in order to have a specific release profile. In accordance with this method, several targeted release profiles were successfully obtained. We expect that the proposed method will allow us to overcome limitations in controlling complicated release mechanisms so that drug delivery systems can be reliably designed to satisfy clinical demands.

Duke Scholars

Published In

Biomaterials

DOI

EISSN

1878-5905

Publication Date

December 2009

Volume

30

Issue

34

Start / End Page

6648 / 6654

Location

Netherlands

Related Subject Headings

  • Pharmacokinetics
  • Microspheres
  • Drug Delivery Systems
  • Drug Compounding
  • Biomedical Engineering
  • Albumins
 

Citation

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MLA
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Lee, W., Wiseman, M. E., Cho, N.-J., Glenn, J. S., & Frank, C. W. (2009). The reliable targeting of specific drug release profiles by integrating arrays of different albumin-encapsulated microsphere types. Biomaterials, 30(34), 6648–6654. https://doi.org/10.1016/j.biomaterials.2009.08.035
Lee, Wonjae, Meredith E. Wiseman, Nam-Joon Cho, Jeffrey S. Glenn, and Curtis W. Frank. “The reliable targeting of specific drug release profiles by integrating arrays of different albumin-encapsulated microsphere types.Biomaterials 30, no. 34 (December 2009): 6648–54. https://doi.org/10.1016/j.biomaterials.2009.08.035.
Lee W, Wiseman ME, Cho N-J, Glenn JS, Frank CW. The reliable targeting of specific drug release profiles by integrating arrays of different albumin-encapsulated microsphere types. Biomaterials. 2009 Dec;30(34):6648–54.
Lee, Wonjae, et al. “The reliable targeting of specific drug release profiles by integrating arrays of different albumin-encapsulated microsphere types.Biomaterials, vol. 30, no. 34, Dec. 2009, pp. 6648–54. Pubmed, doi:10.1016/j.biomaterials.2009.08.035.
Lee W, Wiseman ME, Cho N-J, Glenn JS, Frank CW. The reliable targeting of specific drug release profiles by integrating arrays of different albumin-encapsulated microsphere types. Biomaterials. 2009 Dec;30(34):6648–6654.
Journal cover image

Published In

Biomaterials

DOI

EISSN

1878-5905

Publication Date

December 2009

Volume

30

Issue

34

Start / End Page

6648 / 6654

Location

Netherlands

Related Subject Headings

  • Pharmacokinetics
  • Microspheres
  • Drug Delivery Systems
  • Drug Compounding
  • Biomedical Engineering
  • Albumins