The use of genome sequencing to investigate an outbreak of hospital-acquired mucormycosis in transplant patients.

Journal Article

We report three cases of hospital-acquired mucormycosis in heart and lung transplant patients over a 6-month period. Traditional epidemiological investigation tools were used to look for a common link between patients to explain the outbreak. Genome sequencing of each fungal strain was used to supplement the investigation. By disproving a close genetic link between infecting strains of mucormycosis, we were able to conclude the outbreak investigation. Genome sequencing is a novel tool that can be used in addition to traditional epidemiologic investigations to help determine linkage of patients during outbreak investigations.

Full Text

Duke Authors

Cited Authors

  • Marek, C; Croxen, MA; Dingle, TC; Bharat, A; Schwartz, IS; Wiens, R; Smith, S

Published Date

  • October 2019

Published In

Volume / Issue

  • 21 / 5

Start / End Page

  • e13163 -

PubMed ID

  • 31472083

Electronic International Standard Serial Number (EISSN)

  • 1399-3062

Digital Object Identifier (DOI)

  • 10.1111/tid.13163


  • eng

Conference Location

  • Denmark