Neuromodulation therapy for atrial fibrillation.

Journal Article (Journal Article;Review)

Atrial fibrillation has a multifactorial pathophysiology influenced by cardiac autonomic innervation. Both sympathetic and parasympathetic influences are profibrillatory. Innovative therapies targeting the neurocardiac axis include catheter ablation or pharmacologic suppression of ganglionated plexi, renal sympathetic denervation, low-level vagal stimulation, and stellate ganglion blockade. To date, these therapies have variable efficacy. As our understanding of atrial fibrillation and the cardiac nervous system expands, our approach to therapeutic neuromodulation will continue evolving for the benefit of those with AF.

Full Text

Duke Authors

Cited Authors

  • Karatela, MF; Fudim, M; Mathew, JP; Piccini, JP

Published Date

  • January 2023

Published In

Volume / Issue

  • 20 / 1

Start / End Page

  • 100 - 111

PubMed ID

  • 35988908

Electronic International Standard Serial Number (EISSN)

  • 1556-3871

Digital Object Identifier (DOI)

  • 10.1016/j.hrthm.2022.08.011


  • eng

Conference Location

  • United States