Eradicating Atherosclerosis: Should We Start Statins at Younger Ages and at Lower LDL-Cs.

Journal Article (Journal Article;Review)

PURPOSE OF REVIEW: Given the increasing burden of cardiovascular disease, we review the literature for earlier initiation of statin therapy at younger ages and lower low-density lipoprotein cholesterol (LDL-C) levels, with the goal of preventing the development of atherosclerosis prior to clinical events. RECENT FINDINGS: There is a rising prevalence of dyslipidemia among younger adults. Although guidelines offer recommendations for adults over 40, there is little guidance for the management of younger adults with moderately elevated LDL-C levels. Earlier and more aggressive statin use may slow progression, or even halt atherosclerosis, and may likewise be beneficial and cost-effective on a population level. Further research is needed to define the exact age and LDL-C level at which to start statin therapy. Until then, more detailed risk stratification with lab testing and imaging should be used to identify younger adults at the highest risk.

Full Text

Duke Authors

Cited Authors

  • O'Toole, T; Kelsey, MD; Shah, NP; McGarrah, RW; Pagidipati, NJ

Published Date

  • October 2022

Published In

Volume / Issue

  • 24 / 10

Start / End Page

  • 1397 - 1406

PubMed ID

  • 36006590

Pubmed Central ID

  • PMC10021628

Electronic International Standard Serial Number (EISSN)

  • 1534-3170

Digital Object Identifier (DOI)

  • 10.1007/s11886-022-01760-y


  • eng

Conference Location

  • United States