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Intracellular communication and immunothrombosis in sepsis.

Publication ,  Journal Article
Iba, T; Levi, M; Levy, JH
Published in: J Thromb Haemost
November 2022

Inflammation and coagulation are the critical responses to infection that include leukocytes, platelets, and vascular endothelial cells responding in concert to eradicate the invading pathogen. In sepsis, a variety of cell surface receptors, including toll-like receptors, Fcγ-receptors, G-protein-coupled receptors, and adhesion receptors, detect the pathogens and elicit thromboinflammatory responses. Concurrently, the molecular patterns released from host damaged cells accelerate the immune responses through binding to the same pattern recognition receptors. Cytokines, chemokines, and extracellular vesicles are important mediators for amplifying the responses to distant cells as part of the systemic response to infections. At the same time, cells communicate with each other via direct contact, adhesion molecules, paracrine mediators, and tunneling nanotubes, which are important for regulating inflammation and thrombus formation. Despite increasing attention to immunothrombosis in sepsis, these close communication systems are less understood but play a critical role in host defense mechanisms. In this review, cellular activation and direct intercellular communication systems in sepsis with a focus on the coagulation response will be considered.

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Published In

J Thromb Haemost

DOI

EISSN

1538-7836

Publication Date

November 2022

Volume

20

Issue

11

Start / End Page

2475 / 2484

Location

England

Related Subject Headings

  • Toll-Like Receptors
  • Thromboinflammation
  • Sepsis
  • Receptors, Pattern Recognition
  • Receptors, IgG
  • Inflammation
  • Humans
  • Endothelial Cells
  • Cytokines
  • Cell Communication
 

Citation

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Iba, T., Levi, M., & Levy, J. H. (2022). Intracellular communication and immunothrombosis in sepsis. J Thromb Haemost, 20(11), 2475–2484. https://doi.org/10.1111/jth.15852
Iba, Toshiaki, Marcel Levi, and Jerrold H. Levy. “Intracellular communication and immunothrombosis in sepsis.J Thromb Haemost 20, no. 11 (November 2022): 2475–84. https://doi.org/10.1111/jth.15852.
Iba T, Levi M, Levy JH. Intracellular communication and immunothrombosis in sepsis. J Thromb Haemost. 2022 Nov;20(11):2475–84.
Iba, Toshiaki, et al. “Intracellular communication and immunothrombosis in sepsis.J Thromb Haemost, vol. 20, no. 11, Nov. 2022, pp. 2475–84. Pubmed, doi:10.1111/jth.15852.
Iba T, Levi M, Levy JH. Intracellular communication and immunothrombosis in sepsis. J Thromb Haemost. 2022 Nov;20(11):2475–2484.
Journal cover image

Published In

J Thromb Haemost

DOI

EISSN

1538-7836

Publication Date

November 2022

Volume

20

Issue

11

Start / End Page

2475 / 2484

Location

England

Related Subject Headings

  • Toll-Like Receptors
  • Thromboinflammation
  • Sepsis
  • Receptors, Pattern Recognition
  • Receptors, IgG
  • Inflammation
  • Humans
  • Endothelial Cells
  • Cytokines
  • Cell Communication