Multiaxial fields improve SABRE efficiency by preserving hydride order.

Journal Article (Journal Article)

Signal Amplification By Reversible Exchange (SABRE) and the heteronuclear variant, X-SABRE, increase the sensitivity of magnetic resonance techniques using order derived from reversible binding of para-hydrogen. One current limitation of SABRE is suboptimal polarization transfer over the lifetime of the complex. Here, we demonstrate a multiaxial low-field pulse sequence which allows optimal polarization build-up during a low-field "evolution" pulse, followed by a high-field "mixing" pulse which permits proton decoupling along an orthogonal axis. This preserves the singlet character of the hydrides while allowing exchange to replenish the ligands on the iridium catalyst. This strategy leads to a 2.5-fold improvement over continuous field SABRE SHEATH experimentally which was confirmed with numerical simulation.

Full Text

Duke Authors

Cited Authors

  • Eriksson, SL; Mammen, MW; Eriksson, CW; Lindale, JR; Warren, WS

Published Date

  • August 5, 2022

Published In

Volume / Issue

  • 342 /

Start / End Page

  • 107282 -

PubMed ID

  • 35970048

Electronic International Standard Serial Number (EISSN)

  • 1096-0856

International Standard Serial Number (ISSN)

  • 1090-7807

Digital Object Identifier (DOI)

  • 10.1016/j.jmr.2022.107282

Language

  • eng