Metformin association with lower prostate cancer recurrence in type 2 diabetes: a systematic review and meta-analysis.

Journal Article (Systematic Review;Review;Journal Article)


Accumulating evidence suggests that metformin possesses anticarcinogenic properties, and its use is associated with favorable outcomes in several cancers. However, it remains unclear whether metformin influences prognosis in prostate cancer (PCa) with concurrent type 2 diabetes (T2D).

Materials and methods

We searched PubMed, EMBASE, and the Cochrane Library from database inception to April 16, 2014 without language restrictions to identify studies investigating the effect of metformin treatment on outcomes of PCa with concurrent T2D. We conducted a meta-analysis to quantify the risk of recurrence, progression, cancer-specific mortality, and all-cause mortality. Summary relative risks (RRs) with corresponding 95% confidence intervals (CIs) were calculated. Publication bias was assessed by Begg's rank correlation test.


A total of eight studies fulfilled the eligibility criteria. We found that diabetic PCa patients who did not use metformin were at increased risk of cancer recurrence (RR, 1.20; 95%CI, 1.00-1.44), compared with those who used metformin. A similar trend was observed for other outcomes, but their relationships did not reach statistical significance. Funnel plot asymmetry was not observed among studies reporting recurrence (p=0.086).


Our results suggest that metformin may improve outcomes in PCa patients with concurrent T2D. Well-designed large studies and collaborative basic research are warranted.

Full Text

Duke Authors

Cited Authors

  • Hwang, IC; Park, SM; Shin, D; Ahn, HY; Rieken, M; Shariat, SF

Published Date

  • January 2015

Published In

Volume / Issue

  • 16 / 2

Start / End Page

  • 595 - 600

PubMed ID

  • 25684493

Electronic International Standard Serial Number (EISSN)

  • 2476-762X

International Standard Serial Number (ISSN)

  • 1513-7368

Digital Object Identifier (DOI)

  • 10.7314/apjcp.2015.16.2.595


  • eng