Diet and Exercise in Cancer Metabolism.

Journal Article (Journal Article)

Diet and exercise are modifiable lifestyle factors known to have a major influence on metabolism. Clinical practice addresses diseases of altered metabolism such as diabetes or hypertension by altering these factors. Despite enormous public interest, there are limited defined diet and exercise regimens for patients with cancer. Nevertheless, the molecular basis of cancer has converged over the past 15 years on an essential role for altered metabolism in cancer. However, our understanding of the molecular mechanisms that underlie the impact of diet and exercise on cancer metabolism is in its very early stages. In this perspective, I propose conceptual frameworks for understanding the consequences of diet and exercise on cancer cell metabolism and tumor biology and also highlight recent developments. By advancing our mechanistic understanding, I will discuss actionable ways that such interventions could eventually reach the mainstay of both medical oncology and cancer control and prevention.

Full Text

Duke Authors

Cited Authors

  • Locasale, JW

Published Date

  • October 5, 2022

Published In

Volume / Issue

  • 12 / 10

Start / End Page

  • 2249 - 2257

PubMed ID

  • 36062923

Pubmed Central ID

  • PMC9547953

Electronic International Standard Serial Number (EISSN)

  • 2159-8290

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-22-0096


  • eng

Conference Location

  • United States