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Analysis of albumin as a prognostic factor in HHV-8/HIV-negative Castleman disease from a multicenter study.

Publication ,  Journal Article
Yu, T; Cai, Q-Q; Zhai, Q-L; Li, L; Fang, X; Li, J; Sun, R; Yang, H; Wang, Z; Qian, W; Xu-Monette, ZY; Young, KH; Yu, L
Published in: Leuk Lymphoma
December 2022

As a rare lymphoproliferative disorder, many patients with HHV-8/HIV-negative Castleman disease (CD) have hypoalbuminemia. However, data is limited on whether hypoalbuminemia is an independent predictor of CD. We retrospectively collected data from 230 patients diagnosed at 12 medical centers in China and the U.S. Different classifications included 147 patients with unicentric CD (UCD) and 83 with idiopathic multicentric CD (iMCD). Adjusted smooth curve fitting showed that the relationship between albumin and all-cause death of patients with CD and iMCD was linear. Cox proportional hazards regression modeling showed a negative association between the risk of death and albumin level (hazard ratio [HR]: 0.84; 95% CI, 0.76, 0.93). Using the Kaplan-Meier method, we determined that hypoproteinemia was a risk factor for poorer prognosis in patients with CD, UCD, and iMCD. Albumin was independently and negatively associated with the risk of death in CD patients, especially those with iMCD.

Duke Scholars

Published In

Leuk Lymphoma

DOI

EISSN

1029-2403

Publication Date

December 2022

Volume

63

Issue

13

Start / End Page

3082 / 3091

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Prognosis
  • Immunology
  • Hypoalbuminemia
  • Humans
  • Herpesvirus 8, Human
  • HIV Infections
  • Castleman Disease
  • Albumins
  • 3201 Cardiovascular medicine and haematology
 

Citation

APA
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MLA
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Yu, T., Cai, Q.-Q., Zhai, Q.-L., Li, L., Fang, X., Li, J., … Yu, L. (2022). Analysis of albumin as a prognostic factor in HHV-8/HIV-negative Castleman disease from a multicenter study. Leuk Lymphoma, 63(13), 3082–3091. https://doi.org/10.1080/10428194.2022.2118528
Yu, Tiantian, Qing-Qing Cai, Qiong-Li Zhai, Ling Li, Xiaosheng Fang, Jianyong Li, Ruifang Sun, et al. “Analysis of albumin as a prognostic factor in HHV-8/HIV-negative Castleman disease from a multicenter study.Leuk Lymphoma 63, no. 13 (December 2022): 3082–91. https://doi.org/10.1080/10428194.2022.2118528.
Yu T, Cai Q-Q, Zhai Q-L, Li L, Fang X, Li J, et al. Analysis of albumin as a prognostic factor in HHV-8/HIV-negative Castleman disease from a multicenter study. Leuk Lymphoma. 2022 Dec;63(13):3082–91.
Yu, Tiantian, et al. “Analysis of albumin as a prognostic factor in HHV-8/HIV-negative Castleman disease from a multicenter study.Leuk Lymphoma, vol. 63, no. 13, Dec. 2022, pp. 3082–91. Pubmed, doi:10.1080/10428194.2022.2118528.
Yu T, Cai Q-Q, Zhai Q-L, Li L, Fang X, Li J, Sun R, Yang H, Wang Z, Qian W, Xu-Monette ZY, Young KH, Yu L. Analysis of albumin as a prognostic factor in HHV-8/HIV-negative Castleman disease from a multicenter study. Leuk Lymphoma. 2022 Dec;63(13):3082–3091.

Published In

Leuk Lymphoma

DOI

EISSN

1029-2403

Publication Date

December 2022

Volume

63

Issue

13

Start / End Page

3082 / 3091

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Prognosis
  • Immunology
  • Hypoalbuminemia
  • Humans
  • Herpesvirus 8, Human
  • HIV Infections
  • Castleman Disease
  • Albumins
  • 3201 Cardiovascular medicine and haematology