Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts.
Journal Article (Journal Article;Review)
Human respiratory viruses induce a wide breadth of disease phenotypes and outcomes of varying severity. Innovative models that recapitulate the human respiratory tract are needed to study such viruses, understand the virus-host interactions underlying replication and pathogenesis, and to develop effective countermeasures for prevention and treatment. Human organoid models provide a platform to study virus-host interactions in the proximal to distal lung in the absence of a human in vivo model. These cultures fill the niche of a suitable ex vivo model that represents the in vivo lung environment and encapsulates the structure and function of the native human lung.
- Edwards, CE; Tata, A; Baric, RS
- December 2022
Volume / Issue
- 250 /
Start / End Page
- 36 - 45
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)
- United States