Human lung organoids as a model for respiratory virus replication and countermeasure performance in human hosts.

Journal Article (Journal Article;Review)

Human respiratory viruses induce a wide breadth of disease phenotypes and outcomes of varying severity. Innovative models that recapitulate the human respiratory tract are needed to study such viruses, understand the virus-host interactions underlying replication and pathogenesis, and to develop effective countermeasures for prevention and treatment. Human organoid models provide a platform to study virus-host interactions in the proximal to distal lung in the absence of a human in vivo model. These cultures fill the niche of a suitable ex vivo model that represents the in vivo lung environment and encapsulates the structure and function of the native human lung.

Full Text

Duke Authors

Cited Authors

  • Edwards, CE; Tata, A; Baric, RS

Published Date

  • December 2022

Published In

Volume / Issue

  • 250 /

Start / End Page

  • 36 - 45

PubMed ID

  • 35850445

Electronic International Standard Serial Number (EISSN)

  • 1878-1810

Digital Object Identifier (DOI)

  • 10.1016/j.trsl.2022.07.002


  • eng

Conference Location

  • United States