Skip to main content
Journal cover image

Development and validation of the San Diego Early Test Score to predict acute and early HIV infection risk in men who have sex with men.

Publication ,  Journal Article
Hoenigl, M; Weibel, N; Mehta, SR; Anderson, CM; Jenks, J; Green, N; Gianella, S; Smith, DM; Little, SJ
Published in: Clin Infect Dis
August 1, 2015

BACKGROUND: Although men who have sex with men (MSM) represent a dominant risk group for human immunodeficiency virus (HIV), the risk of HIV infection within this population is not uniform. The objective of this study was to develop and validate a score to estimate incident HIV infection risk. METHODS: Adult MSM who were tested for acute and early HIV (AEH) between 2008 and 2014 were retrospectively randomized 2:1 to a derivation and validation dataset, respectively. Using the derivation dataset, each predictor associated with an AEH outcome in the multivariate prediction model was assigned a point value that corresponded to its odds ratio. The score was validated on the validation dataset using C-statistics. RESULTS: Data collected at a single HIV testing encounter from 8326 unique MSM were analyzed, including 200 with AEH (2.4%). Four risk behavior variables were significantly associated with an AEH diagnosis (ie, incident infection) in multivariable analysis and were used to derive the San Diego Early Test (SDET) score: condomless receptive anal intercourse (CRAI) with an HIV-positive MSM (3 points), the combination of CRAI plus ≥5 male partners (3 points), ≥10 male partners (2 points), and diagnosis of bacterial sexually transmitted infection (2 points)-all as reported for the prior 12 months. The C-statistic for this risk score was >0.7 in both data sets. CONCLUSIONS: The SDET risk score may help to prioritize resources and target interventions, such as preexposure prophylaxis, to MSM at greatest risk of acquiring HIV infection. The SDET risk score is deployed as a freely available tool at http://sdet.ucsd.edu.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

August 1, 2015

Volume

61

Issue

3

Start / End Page

468 / 475

Location

United States

Related Subject Headings

  • Risk Assessment
  • Retrospective Studies
  • Reproducibility of Results
  • Random Allocation
  • Microbiology
  • Male
  • Humans
  • Homosexuality, Male
  • HIV Infections
  • Adult
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hoenigl, M., Weibel, N., Mehta, S. R., Anderson, C. M., Jenks, J., Green, N., … Little, S. J. (2015). Development and validation of the San Diego Early Test Score to predict acute and early HIV infection risk in men who have sex with men. Clin Infect Dis, 61(3), 468–475. https://doi.org/10.1093/cid/civ335
Hoenigl, Martin, Nadir Weibel, Sanjay R. Mehta, Christy M. Anderson, Jeffrey Jenks, Nella Green, Sara Gianella, Davey M. Smith, and Susan J. Little. “Development and validation of the San Diego Early Test Score to predict acute and early HIV infection risk in men who have sex with men.Clin Infect Dis 61, no. 3 (August 1, 2015): 468–75. https://doi.org/10.1093/cid/civ335.
Hoenigl M, Weibel N, Mehta SR, Anderson CM, Jenks J, Green N, et al. Development and validation of the San Diego Early Test Score to predict acute and early HIV infection risk in men who have sex with men. Clin Infect Dis. 2015 Aug 1;61(3):468–75.
Hoenigl, Martin, et al. “Development and validation of the San Diego Early Test Score to predict acute and early HIV infection risk in men who have sex with men.Clin Infect Dis, vol. 61, no. 3, Aug. 2015, pp. 468–75. Pubmed, doi:10.1093/cid/civ335.
Hoenigl M, Weibel N, Mehta SR, Anderson CM, Jenks J, Green N, Gianella S, Smith DM, Little SJ. Development and validation of the San Diego Early Test Score to predict acute and early HIV infection risk in men who have sex with men. Clin Infect Dis. 2015 Aug 1;61(3):468–475.
Journal cover image

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

August 1, 2015

Volume

61

Issue

3

Start / End Page

468 / 475

Location

United States

Related Subject Headings

  • Risk Assessment
  • Retrospective Studies
  • Reproducibility of Results
  • Random Allocation
  • Microbiology
  • Male
  • Humans
  • Homosexuality, Male
  • HIV Infections
  • Adult