Invasive aspergillosis in critically ill patients: Review of definitions and diagnostic approaches.

Journal Article (Journal Article;Review)

Invasive aspergillosis (IA) is an increasingly recognised phenomenon in critically ill patients in the intensive care unit, including in patients with severe influenza and severe coronavirus disease 2019 (COVID-19) infection. To date, there are no consensus criteria on how to define IA in the ICU population, although several criteria are used, including the AspICU criteria and new consensus criteria to categorise COVID-19-associated pulmonary aspergillosis (CAPA). In this review, we describe the epidemiology of IA in critically ill patients, most common definitions used to define IA in this population, and most common clinical specimens obtained for establishing a mycological diagnosis of IA in the critically ill. We also review the most common diagnostic tests used to diagnose IA in this population, and lastly discuss the most common clinical presentation and imaging findings of IA in the critically ill and discuss areas of further needed investigation.

Full Text

Duke Authors

Cited Authors

  • Jenks, JD; Nam, HH; Hoenigl, M

Published Date

  • September 2021

Published In

Volume / Issue

  • 64 / 9

Start / End Page

  • 1002 - 1014

PubMed ID

  • 33760284

Electronic International Standard Serial Number (EISSN)

  • 1439-0507

Digital Object Identifier (DOI)

  • 10.1111/myc.13274


  • eng

Conference Location

  • Germany