Breakthrough invasive fungal infections: Who is at risk?

Journal Article (Journal Article;Review)

The epidemiology of invasive fungal infections (IFIs) in immunocompromised individuals has changed over the last few decades, partially due to the increased use of antifungal agents to prevent IFIs. Although this strategy has resulted in an overall reduction in IFIs, a subset of patients develop breakthrough IFIs with substantial morbidity and mortality in this population. Here, we review the most significant risk factors for breakthrough IFIs in haematology patients, solid organ transplant recipients, and patients in the intensive care unit, focusing particularly on host factors, and highlight areas that require future investigation.

Full Text

Duke Authors

Cited Authors

  • Jenks, JD; Cornely, OA; Chen, SC-A; Thompson, GR; Hoenigl, M

Published Date

  • October 2020

Published In

Volume / Issue

  • 63 / 10

Start / End Page

  • 1021 - 1032

PubMed ID

  • 32744334

Electronic International Standard Serial Number (EISSN)

  • 1439-0507

Digital Object Identifier (DOI)

  • 10.1111/myc.13148


  • eng

Conference Location

  • Germany