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Individualized Approach in the Surgical Management of Hepatocellular Carcinoma: Results from a Greek Multicentre Study.

Publication ,  Journal Article
Glantzounis, GK; Korkolis, D; Sotiropoulos, GC; Tzimas, G; Karampa, A; Paliouras, A; Asimakopoulos, A-G; Davakis, S; Papalampros, A; Moris, D ...
Published in: Cancers
September 2022

Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the third leading cause of death worldwide. The management of HCC is complex, with surgical treatment providing long-term survival in eligible patients. This study aims to present the experience of aggressive surgical management of HCC in Greece. Methods: This is a retrospective multicentre clinical study with 242 patients. Results: Most patients were male (79%) and had a median age of 71 yrs. According to the most recent BCLC criteria, 172 patients (71.1%) were classified as BCLC 0-A stage, 33 patients (13.6%) were classified as BCLC B, and 37 (15.3%) were classified as BCLC C. A total of 54% of the patients underwent major hepatectomy. Major postoperative morbidity was 15.6%, and the 90-day postoperative mortality rate was 4.5%. The median follow-up was 33.5 months. Three- and five-year overall survival was 65% and 48%, respectively. The median overall survival was 55 months. Significantly, five-year survival was 55% for BCLC A, and 34% and 21% for BCLC B and C, respectively. In univariate analysis, cirrhosis, type of resection (R status), and BCLC stage were associated with overall survival. Multivariate analysis indicated that R1 and R2 resections compared to R0, and BCLC C compared to BCLC 0-A, were independently associated with increased mortality. Conclusions: Aggressive surgical treatment of HCC offers satisfactory long-term survival prospects. A significant percentage (29%) of HCCs that underwent liver resection were of the intermediate and advanced BCLC stage. The management of patients with HCC should be discussed in multidisciplinary tumour board meetings on a case-by-case basis to be more effective.

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Published In

Cancers

DOI

EISSN

2072-6694

ISSN

2072-6694

Publication Date

September 2022

Volume

14

Issue

18

Start / End Page

4387

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Glantzounis, G. K., Korkolis, D., Sotiropoulos, G. C., Tzimas, G., Karampa, A., Paliouras, A., … Felekouras, E. (2022). Individualized Approach in the Surgical Management of Hepatocellular Carcinoma: Results from a Greek Multicentre Study. Cancers, 14(18), 4387. https://doi.org/10.3390/cancers14184387
Glantzounis, Georgios K., Dimitrios Korkolis, Georgios C. Sotiropoulos, Georgios Tzimas, Anastasia Karampa, Athanasios Paliouras, Alexandros-Georgios Asimakopoulos, et al. “Individualized Approach in the Surgical Management of Hepatocellular Carcinoma: Results from a Greek Multicentre Study.Cancers 14, no. 18 (September 2022): 4387. https://doi.org/10.3390/cancers14184387.
Glantzounis GK, Korkolis D, Sotiropoulos GC, Tzimas G, Karampa A, Paliouras A, et al. Individualized Approach in the Surgical Management of Hepatocellular Carcinoma: Results from a Greek Multicentre Study. Cancers. 2022 Sep;14(18):4387.
Glantzounis, Georgios K., et al. “Individualized Approach in the Surgical Management of Hepatocellular Carcinoma: Results from a Greek Multicentre Study.Cancers, vol. 14, no. 18, Sept. 2022, p. 4387. Epmc, doi:10.3390/cancers14184387.
Glantzounis GK, Korkolis D, Sotiropoulos GC, Tzimas G, Karampa A, Paliouras A, Asimakopoulos A-G, Davakis S, Papalampros A, Moris D, Felekouras E. Individualized Approach in the Surgical Management of Hepatocellular Carcinoma: Results from a Greek Multicentre Study. Cancers. 2022 Sep;14(18):4387.

Published In

Cancers

DOI

EISSN

2072-6694

ISSN

2072-6694

Publication Date

September 2022

Volume

14

Issue

18

Start / End Page

4387

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis