Dendritic-NK cell interactions in P. gingivalis-specific responses.

Journal Article (Journal Article)

Patients with localized aggressive periodontitis have type-1 cytokines in gingival crevicular fluid and high titers of IFN-gamma-dependent IgG2 reactive with P. gingivalis in gingival crevicular fluid and serum. Localized aggressive periodontitis monocytes spontaneously differentiate into dendritic cells that can stimulate IFN-gamma production by NK cells. These relationships prompted the hypothesis that P. gingivalis-dendritic cell-NK cell interactions might promote type-1 cytokine responses. Although P. gingivalis is not a potent inducer of Th1 responses, it stimulated strong IL-12 responses by monocyte-derived dendritic cells in the presence of IFN-gamma, and IFN-gamma was produced by NK cells within 24 hrs in the presence of dendritic cells. Anti-P. gingivalis IgG2 responses were enhanced by dendritic cells, and removal of NK cells reduced IFN-gamma- and P. gingivalis-specific IgG2. Thus, P. gingivalis-dendritic cell-NK cell interactions apparently resulted in reciprocal stimulation and increased type-1 cytokine production by both dendritic cells and NK cells, and increased P. gingivalis-specific IgG2.

Full Text

Duke Authors

Cited Authors

  • Kikuchi, T; Willis, DL; Liu, M; Purkall, DB; Sukumar, S; Barbour, SE; Schenkein, HA; Tew, JG

Published Date

  • September 2005

Published In

Volume / Issue

  • 84 / 9

Start / End Page

  • 858 - 862

PubMed ID

  • 16109998

International Standard Serial Number (ISSN)

  • 0022-0345

Digital Object Identifier (DOI)

  • 10.1177/154405910508400915

Language

  • eng

Conference Location

  • United States