Surround Inhibition Mediates Pain Relief by Low Amplitude Spinal Cord Stimulation: Modeling and Measurement.

Journal Article (Journal Article)

Low-frequency (<200 Hz), subperception spinal cord stimulation (SCS) is a novel modality demonstrating therapeutic efficacy for treating chronic neuropathic pain. When stimulation parameters were carefully titrated, patients experienced rapid onset (seconds-minutes) pain relief without paresthesia, but the mechanisms of action are unknown. Using an integrated computational model and in vivo measurements in urethane-anesthetized rats, we quantified how stimulation parameters (placement, pulse width, frequency, and amplitude) influenced dorsal column (DC) axon activation and neural responses in the dorsal horn (DH). Both modeled and recorded DC axons responded with irregular spiking patterns in response to low-amplitude SCS. Maximum inhibition of DH neurons occurred at ∼80% of the predicted sensory threshold in both modeled and recorded neurons, and responses were strongly dependent on spatially targeting of stimulation, i.e., the complement of DC axons activated, and on stimulation parameters. Intrathecal administration of bicuculline shifted neural responses to low-amplitude stimulation in both the model and experiment, suggesting that analgesia is dependent on segmental GABAergic mechanisms. Our results support the hypothesis that low-frequency subperception SCS generates rapid analgesia by activating a small number of DC axons which inhibit DH neuron activity via surround inhibition.

Full Text

Duke Authors

Cited Authors

  • Gilbert, JE; Titus, N; Zhang, T; Esteller, R; Grill, WM

Published Date

  • September 2022

Published In

Volume / Issue

  • 9 / 5

Start / End Page

  • ENEURO.0058 - ENEU22.2022

PubMed ID

  • 36150892

Pubmed Central ID

  • PMC9536854

Electronic International Standard Serial Number (EISSN)

  • 2373-2822

International Standard Serial Number (ISSN)

  • 2373-2822

Digital Object Identifier (DOI)

  • 10.1523/eneuro.0058-22.2022

Language

  • eng