Effect of excessive gestational weight gain on insulin sensitivity and insulin kinetics in women with overweight/obesity.

Journal Article (Journal Article)

OBJECTIVE: Obesity increases the risk for pregnancy complications and maternal hyperglycemia. The Institute of Medicine developed guidelines for gestational weight gain (GWG) targets for women with overweight/obesity, but it is unclear whether exceeding these targets has adverse effects on maternal glucose metabolism. METHODS: Insulin sensitivity (assessed using the Matsuda Insulin Sensitivity Index), β-cell function (assessed as insulin secretion rate in relation to plasma glucose), and plasma insulin clearance rate were evaluated using a frequently sampled oral glucose tolerance test at 15 and 35 weeks of gestation in 184 socioeconomically disadvantaged African American women with overweight/obesity. RESULTS: Insulin sensitivity decreased, whereas β-cell function and insulin clearance increased from 15 to 35 weeks of gestation in the entire group. Compared with women who achieved the recommended GWG, excessive GWG was associated with a greater decrease in insulin sensitivity between 15 and 35 weeks. β-cell function and plasma insulin clearance were not affected by excessive GWG. CONCLUSIONS: These data demonstrate that gaining more weight during pregnancy than recommended by the Institute of Medicine is associated with functional effects on glucose metabolism.

Full Text

Duke Authors

Cited Authors

  • Cade, WT; Mittendorfer, B; Patterson, BW; Haire-Joshu, D; Cahill, AG; Stein, RI; Schechtman, KB; Tinius, RA; Brown, K; Klein, S

Published Date

  • October 2022

Published In

Volume / Issue

  • 30 / 10

Start / End Page

  • 2014 - 2022

PubMed ID

  • 36150208

Pubmed Central ID

  • PMC9512396

Electronic International Standard Serial Number (EISSN)

  • 1930-739X

Digital Object Identifier (DOI)

  • 10.1002/oby.23533


  • eng

Conference Location

  • United States