Racial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium.

Journal Article (Journal Article)

BACKGROUND: Obesity disproportionately affects African American (AA) women and has been shown to increase ovarian cancer risk, with some suggestions that the association may differ by race. METHODS: We evaluated body mass index (BMI) and invasive epithelial ovarian cancer (EOC) risk in a pooled study of case-control and nested case-control studies including AA and White women. We evaluated both young adult and recent BMI (within the last 5 years). Associations were estimated using multi-level and multinomial logistic regression models. RESULTS: The sample included 1078 AA cases, 2582 AA controls, 3240 White cases and 9851 White controls. We observed a higher risk for the non-high-grade serous (NHGS) histotypes for AA women with obesity (ORBMI 30+= 1.62, 95% CI: 1.16, 2.26) and White women with obesity (ORBMI 30+= 1.20, 95% CI: 1.02, 2.42) compared to non-obese. Obesity was associated with higher NHGS risk in White women who never used HT (ORBMI 30+= 1.40, 95% CI: 1.08, 1.82). Higher NHGS ovarian cancer risk was observed for AA women who ever used HT (ORBMI 30+= 2.66, 95% CI: 1.15, 6.13), while in White women, there was an inverse association between recent BMI and risk of EOC and HGS in ever-HT users (EOC ORBMI 30+= 0.81, 95% CI: 0.69, 0.95, HGS ORBMI 30+= 0.73, 95% CI: 0.61, 0.88). CONCLUSION: Obesity contributes to NHGS EOC risk in AA and White women, but risk across racial groups studied differs by HT use and histotype.

Full Text

Duke Authors

Cited Authors

  • Ochs-Balcom, HM; Johnson, C; Guertin, KA; Qin, B; Beeghly-Fadiel, A; Camacho, F; Bethea, TN; Dempsey, LF; Rosenow, W; Joslin, CE; Myers, E; Moorman, PG; Harris, HR; Peres, LC; Wendy Setiawan, V; Wu, AH; Rosenberg, L; Schildkraut, JM; Bandera, EV

Published Date

  • November 2022

Published In

Volume / Issue

  • 127 / 11

Start / End Page

  • 1983 - 1990

PubMed ID

  • 36138071

Pubmed Central ID

  • PMC9681872

Electronic International Standard Serial Number (EISSN)

  • 1532-1827

Digital Object Identifier (DOI)

  • 10.1038/s41416-022-01981-6


  • eng

Conference Location

  • England