Systemic Therapy Approaches for Breast Cancer Brain and Leptomeningeal Metastases.
Publication
, Journal Article
Dhakal, A; Van Swearingen, AED; O'Regan, R; Anders, CK
Published in: Curr Treat Options Oncol
October 2022
Brain metastasis arising from breast cancer is associated with a poor prognosis. Various systemic chemotherapy and targeted therapies which are effective against breast cancer often fail to provide benefits against brain metastasis. This is mainly due to limited penetration of the therapies across the blood-brain barrier, and divergent evolution of brain metastasis compared to the primary tumor. Thus, brain metastasis is typically treated upfront with local therapies, such as surgery and radiation, followed by systemic therapies. Systemic therapies with CNS permeability are favored in patients with brain metastasis. This paper reviews various systemic therapy options for breast cancer brain metastasis.
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Published In
Curr Treat Options Oncol
DOI
EISSN
1534-6277
Publication Date
October 2022
Volume
23
Issue
10
Start / End Page
1457 / 1476
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Humans
- Female
- Breast Neoplasms
- Brain Neoplasms
- Blood-Brain Barrier
Citation
APA
Chicago
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MLA
NLM
Dhakal, A., Van Swearingen, A. E. D., O’Regan, R., & Anders, C. K. (2022). Systemic Therapy Approaches for Breast Cancer Brain and Leptomeningeal Metastases. Curr Treat Options Oncol, 23(10), 1457–1476. https://doi.org/10.1007/s11864-022-01011-w
Dhakal, Ajay, Amanda E. D. Van Swearingen, Ruth O’Regan, and Carey K. Anders. “Systemic Therapy Approaches for Breast Cancer Brain and Leptomeningeal Metastases.” Curr Treat Options Oncol 23, no. 10 (October 2022): 1457–76. https://doi.org/10.1007/s11864-022-01011-w.
Dhakal A, Van Swearingen AED, O’Regan R, Anders CK. Systemic Therapy Approaches for Breast Cancer Brain and Leptomeningeal Metastases. Curr Treat Options Oncol. 2022 Oct;23(10):1457–76.
Dhakal, Ajay, et al. “Systemic Therapy Approaches for Breast Cancer Brain and Leptomeningeal Metastases.” Curr Treat Options Oncol, vol. 23, no. 10, Oct. 2022, pp. 1457–76. Pubmed, doi:10.1007/s11864-022-01011-w.
Dhakal A, Van Swearingen AED, O’Regan R, Anders CK. Systemic Therapy Approaches for Breast Cancer Brain and Leptomeningeal Metastases. Curr Treat Options Oncol. 2022 Oct;23(10):1457–1476.
Published In
Curr Treat Options Oncol
DOI
EISSN
1534-6277
Publication Date
October 2022
Volume
23
Issue
10
Start / End Page
1457 / 1476
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Humans
- Female
- Breast Neoplasms
- Brain Neoplasms
- Blood-Brain Barrier