A complex pattern of disposition of phenytoin in severe intoxication.
Journal Article (Journal Article)
A 5-year-old child developed phenytoin (diphenylhydantoin, DPH) toxicity after receiving 500 mg of the drug daily for 3 weeks. Plasma, urine, and duodenal fluid were collected for assay of DPH and its metabolites. The peak plasma concentration of DPH was 108 mug/ml, and the decline in plasma level did not fit first-order kinetics. The para-hydroxy, meta-hydroxy, and dihydrodiol metabolites of DPH were measured in urine; duodenal aspirate contained both DPH and the para-hydroxy metabolite. Plasma pH may affect distribution of DPH since in vitro binding of DPH to human albumin increased as pH increased.
- Pruitt, AW; Zwiren, GT; Patterson, JH; Dayton, PG; Cook, CE; Wall, ME
- July 1975
Volume / Issue
- 18 / 1
Start / End Page
- 112 - 120
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States