A complex pattern of disposition of phenytoin in severe intoxication.

Journal Article (Journal Article)

A 5-year-old child developed phenytoin (diphenylhydantoin, DPH) toxicity after receiving 500 mg of the drug daily for 3 weeks. Plasma, urine, and duodenal fluid were collected for assay of DPH and its metabolites. The peak plasma concentration of DPH was 108 mug/ml, and the decline in plasma level did not fit first-order kinetics. The para-hydroxy, meta-hydroxy, and dihydrodiol metabolites of DPH were measured in urine; duodenal aspirate contained both DPH and the para-hydroxy metabolite. Plasma pH may affect distribution of DPH since in vitro binding of DPH to human albumin increased as pH increased.

Full Text

Duke Authors

Cited Authors

  • Pruitt, AW; Zwiren, GT; Patterson, JH; Dayton, PG; Cook, CE; Wall, ME

Published Date

  • July 1975

Published In

Volume / Issue

  • 18 / 1

Start / End Page

  • 112 - 120

PubMed ID

  • 238781

International Standard Serial Number (ISSN)

  • 0009-9236

Digital Object Identifier (DOI)

  • 10.1002/cpt1975181112


  • eng

Conference Location

  • United States