Skip to main content

Plasma delta-9-tetrahydrocannabinol in pregnant sheep and fetus after inhalation of smoke from a marijuana cigarette.

Publication ,  Journal Article
Abrams, RM; Cook, CE; Davis, KH; Niederreither, K; Jaeger, MJ; Szeto, HH
Published in: Alcohol Drug Res
1985

Seven pregnant ewes were prepared with open-ended tracheal T tubes and with catheters in maternal femoral artery and in central circulation of fetus. Several days postoperatively, at 129-132 days gestation, ewes inhaled smoke from one marijuana cigarette containing 3.19% delta-9-tetrahydrocannabinol (delta-9-THC). Smoke was produced continuously in a hand-held chamber and delivered to the protruding arm of the tracheal tube. Samples of maternal and fetal blood were taken during the 8-10 minute smoking period and at intervals up to 24 hours. Delta-9-THC was detected in maternal plasma at 3 minutes and peaked at 10 minutes. Fetal plasma delta-9-THC reached detectable levels in 5 animals by 10 minutes. Maximum mean level was reached at 90 minutes and remained nearly constant until the fourth hour. Fetal delta-9-THC levels remained lower than maternal levels at all times. The terminal half-life of delta-9-THC in fetal and maternal plasma exceeded 10 hours.

Duke Scholars

Published In

Alcohol Drug Res

ISSN

0883-1386

Publication Date

1985

Volume

6

Issue

5

Start / End Page

361 / 369

Location

United States

Related Subject Headings

  • Time Factors
  • Sheep
  • Pregnancy
  • Gestational Age
  • Fetus
  • Female
  • Dronabinol
  • Cannabis
  • Body Weight
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Abrams, R. M., Cook, C. E., Davis, K. H., Niederreither, K., Jaeger, M. J., & Szeto, H. H. (1985). Plasma delta-9-tetrahydrocannabinol in pregnant sheep and fetus after inhalation of smoke from a marijuana cigarette. Alcohol Drug Res, 6(5), 361–369.
Abrams, R. M., C. E. Cook, K. H. Davis, K. Niederreither, M. J. Jaeger, and H. H. Szeto. “Plasma delta-9-tetrahydrocannabinol in pregnant sheep and fetus after inhalation of smoke from a marijuana cigarette.Alcohol Drug Res 6, no. 5 (1985): 361–69.
Abrams RM, Cook CE, Davis KH, Niederreither K, Jaeger MJ, Szeto HH. Plasma delta-9-tetrahydrocannabinol in pregnant sheep and fetus after inhalation of smoke from a marijuana cigarette. Alcohol Drug Res. 1985;6(5):361–9.
Abrams, R. M., et al. “Plasma delta-9-tetrahydrocannabinol in pregnant sheep and fetus after inhalation of smoke from a marijuana cigarette.Alcohol Drug Res, vol. 6, no. 5, 1985, pp. 361–69.
Abrams RM, Cook CE, Davis KH, Niederreither K, Jaeger MJ, Szeto HH. Plasma delta-9-tetrahydrocannabinol in pregnant sheep and fetus after inhalation of smoke from a marijuana cigarette. Alcohol Drug Res. 1985;6(5):361–369.

Published In

Alcohol Drug Res

ISSN

0883-1386

Publication Date

1985

Volume

6

Issue

5

Start / End Page

361 / 369

Location

United States

Related Subject Headings

  • Time Factors
  • Sheep
  • Pregnancy
  • Gestational Age
  • Fetus
  • Female
  • Dronabinol
  • Cannabis
  • Body Weight
  • Animals