Copper-catalyzed cyclization of steroidal acylaminoacetylenes: syntheses of novel 11beta-aryl-17,17- spiro[(4'H,5'-methylene)oxazol]-substituted steroids.

Journal Article (Journal Article)

A variety of novel 11beta-aryl-17,17-spiro[(4'H,5'-methylene)oxazol]-substituted steroids have been synthesized in moderate to good yields via copper-catalyzed cyclization of acylaminoacetylenes. The best result was obtained with a catalytic amount of CuI in 1:1 benzene-Et3N at 90 degrees C for 30 min (Ar = 3,4-difluorophenyl; R = ethyl; 97% yield).

Full Text

Duke Authors

Cited Authors

  • Jin, C; Burgess, JP; Kepler, JA; Cook, CE

Published Date

  • May 10, 2007

Published In

Volume / Issue

  • 9 / 10

Start / End Page

  • 1887 - 1890

PubMed ID

  • 17439133

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol070447d

Language

  • eng

Conference Location

  • United States