Emerging antiviral therapeutics for human adenovirus infection: Recent developments and novel strategies.

Journal Article (Journal Article;Review)

Human adenoviruses (HAdV) are ubiquitous human pathogens that cause a significant burden of respiratory, ocular, and gastrointestinal illnesses. Although HAdV infections are generally self-limiting, pediatric and immunocompromised individuals are at particular risk for developing severe disease. Currently, no approved antiviral therapies specific to HAdV exist. Recent outbreaks underscore the need for effective antiviral agents to treat life-threatening infections. In this review we will focus on recent developments in search of potential therapeutic agents for controlling HAdV infections, with a focus on those targeting post-entry stages of the virus replicative cycle.

Full Text

Duke Authors

Cited Authors

  • Dodge, MJ; MacNeil, KM; Tessier, TM; Weinberg, JB; Mymryk, JS

Published Date

  • April 2021

Published In

Volume / Issue

  • 188 /

Start / End Page

  • 105034 -

PubMed ID

  • 33577808

Pubmed Central ID

  • PMC7965347

Electronic International Standard Serial Number (EISSN)

  • 1872-9096

Digital Object Identifier (DOI)

  • 10.1016/j.antiviral.2021.105034


  • eng

Conference Location

  • Netherlands